Clinical Hemorheology and Microcirculation - Volume 7, issue 5

Article Type: Editorial

DOI: 10.3233/CH-1987-7511

Citation: Clinical Hemorheology and Microcirculation, vol. 7, no. 5, pp. I-III, 1987

Authors: Ehrly, A.M. | Fuchs, H.

Article Type: Research Article

Abstract: In healthy volunteers and patients with severe chronic occlusive arterial diseases, Urokinase was given intravenously. There is a dose dependend decrease in fibrinogen concentration, whole blood viscosity, plasma viscosity and red cell aggregability whereas red cell filtrability remains unchanged. This influence of Urokinase on the flow properties of blood could be responsible for some clinical improvements in patients with vascular disorders even when a thrombolytic effect is not yet detectable. Long term systemic low dose Urokinase treatment could be a promising approach in severe stages of ischemic diseases.

Keywords: Low dose Urokinase, blood viscosity, erythrocyte aggregation

DOI: 10.3233/CH-1987-7501

Citation: Clinical Hemorheology and Microcirculation, vol. 7, no. 5, pp. 665-669, 1987

Authors: Liao, Fu-long | Li, Wen | Huang, Shen

Article Type: Research Article

Abstract: HAAKE Rotovisco RV100/CV100 was employed to investigate coagulation of whole blood, platelet rich plasma (PRP) and plasma. Samples were anticoagulated with sodium citrate. Clotting was initiated by adding CaCl2 Shear stress versus time at shear rate 0.3 s−1 at 37°C was recorded. Two parameters were established: (1) Recalcification time tr ; and (2) viscosity increasing rate dη /dt. The parameters appeared to be meaningful to the clotting behaviour of blood, PRP and plasma. Several antithrombotics were tested by the method. Warfarin prolonged tr with a dramatic suppression of dη /dt (P<0.001). Aspirin decreased dη /dt (P<0.001) without …significant influence on tr . Heparin showed dose-response correlations for both the parameters. The unconventional test of clotting by rotational viscometer may have its potential in clinical practice of hemorheology. Show more

Keywords: Hemorheology, Blood viscosity, Clotting, Antithrombotics, Aspirin, Heparin

DOI: 10.3233/CH-1987-7502

Citation: Clinical Hemorheology and Microcirculation, vol. 7, no. 5, pp. 671-677, 1987

Authors: Heilmann, L. | Hirche, H.

Article Type: Research Article

Abstract: 20 pre-eclamptic patients were treated with NAFTIDROFURYL 400 mg i.v. every day over 3 weeks. During infusion as well as before and 4 weeks after treatment rheological parameters were assessed. We found a definite improvement in erythrocyte fluidity by no change in erythrocyte aggregation and plasma viscosity. The elevated blood pressure dropped to the normal range. There were only 2 treatment failures with fetal asphyxia and subsequent cesarean section.

Keywords: Hemorheology, Pre-eclampsia, Naftidrofuryl

DOI: 10.3233/CH-1987-7503

Citation: Clinical Hemorheology and Microcirculation, vol. 7, no. 5, pp. 679-686, 1987

Authors: Käßer, U. | Altrock, G. | Heimburg, P.

Article Type: Research Article

Abstract: Thirty healthy persons have been investigated during one month for the variation of their rheological parameters. Whole blood viscoelasticity and plasma viscosity were determined by means of oscillating capillary flow. The groups examined comprised of 5 women (group A; mean age 23 y.) using oral contraceptives, 17 women (group B; mean age 23 y.) without use of oral contraceptives, and 8 men (group C; mean age 24 y.) as a control for longitudinal comparison. The groups were matched regarding to their age, their concentration of serumproteins, lipids, and ESR (erythrocyte sedimentation rate) as shown in table 1. The rheological data …were standardized to a hematocrit of 45 %. The same values for viscoelastic parameters were found for group A and B, whilst mean cell counts were constant for all groups. Longitudinal variation of viscoelasticity did not differ between men and women, indicating that no specific factor exists that affects rheological properties during menstrual cycle. Show more

Keywords: Hemorheology, menstrual cycle, blood viscoelasticity, plasma viscosity, fibrinogen

DOI: 10.3233/CH-1987-7504

Citation: Clinical Hemorheology and Microcirculation, vol. 7, no. 5, pp. 687-693, 1987

Authors: Caimi, Gregorio | Savettieri, Giovanni | Fierro, Brigida | Catania, Anna | Sarno, Antonio

Article Type: Research Article

Abstract: In 21 untreated subjects with definite multiple sclerosis (MS) we evaluated whole-blood viscosity at high and low shear rates, plasma and serum viscosity, haematocrit, fibrinogen, fibrinogen/albumin ratio, MEA and whole-blood filterability. From the obtained data, it is evident that whole-blood viscosity at high shear rates is reduced in MS compared to controls;no difference is evident at low shear rates. Plasma and serum viscosity as well as the haematocrit are lower in MS. Increased are instead the fibrinogen, fibrinogen/albumin ratio and MEA. No difference is present for VBC .

Keywords: multiple sclerosis, haemorheological determinants

DOI: 10.3233/CH-1987-7505

Citation: Clinical Hemorheology and Microcirculation, vol. 7, no. 5, pp. 695-698, 1987

Authors: Starc, Thomas J. | Schmalzer, Emily A. | Chien, Shu

Article Type: Research Article

Abstract: The effect of beta adrenergic agents on granulocyte deformability was investigated using the filtration technique. Three groups of granulocytes were studied: 1) cells treated with isoproterenol (10−6 to 10−3 M); 2) cells treated with propranolol (10−6 to 10−3 M); and 3) control cells. Granulocytes were pumped at a constant rate through polycarbonate filters with 5 µm diameter pores. The pressure generated as the cell suspension was pumped through the filter reflected the deformability of the cells. Isoproterenol in concentrations ranging between 10−6 to 10−3 M and propranolol in concentrations < 3.5 × 10−4 …M did not change the filtration pressure of granulocytes. Propranolol in concentrations ≥ 3.5 × 10−4 M increased the filtration pressure. This decrease in deformability of granulocytes was associated with a loss of pseudopod formation and a decrease in percent viability. High doses of propranolol decrease granulocyte deformability. Show more

Keywords: Granulocyte Deformability, Filtration, Propranolol, Isoproterenol

DOI: 10.3233/CH-1987-7506

Citation: Clinical Hemorheology and Microcirculation, vol. 7, no. 5, pp. 699-706, 1987

Authors: Berling, C. | Lacombe, C. | Lelievre, J.C.

Article Type: Research Article

Abstract: An hemorheological investigation is performed on renal transplant patients whose graft function was normal and who suffered for the most from erythrocytosis. The aim of this work is to evaluate the hemorheological state of those patients and to show up the possible relationship between viscometric data and post-transplant complications. Blood rheological study is performed using a Couette viscometer. Unsteady flow measurements related to the blood viscoelasticity and thixotropy are recorded, so that measurements in steady flow conditions related to the shear-thinning of blood. The rheological properties of blood are shown to be strongly related to the clinical progress of the …patients. The main result is a relationship between important post-transplant complications and a pathological erythrocyte disaggregability. Show more

Keywords: hemorheology, renal transplantation, erythrocytosis, blood viscosity, red blood cell aggregation

DOI: 10.3233/CH-1987-7507

Citation: Clinical Hemorheology and Microcirculation, vol. 7, no. 5, pp. 707-713, 1987

Authors: Bogar, L. | Morison, I. | Matrai, A. | Tekeres, M. | Nash, G.B. | Flute, P.T. | Dormandy, J.A.

Article Type: Research Article

Abstract: Fractional filtration experiments were carried out to study the transit of white blood cells through 5 µm polycarbonate filters in a constant pressure system. The proportion of white blood cells filtered increases from 24% to 78% from the first to the seventh fraction filtered, while the red blood cell concentration remained unchanged. The filtration rate of blood (relative to the medium) with a constant red cell concentration but different concentrations of white blood cells was determined. The relative filtration rate versus filtered volume showed linear relationship if the concentration of white blood cells was less than 0.25 × 109 …/l in the non-filtered sample. At higher concentrations of white blood cells the function became non-linear making it more difficult to determine the initial relative filtration rate. A comparison of the two types of experiments provided a function between the number of trapped white blood cells and relative filtration rate of suspension indicating the importance of white blood cells in filtration experiments. Show more

Keywords: Erythrocyte filtration, Leucocyte filterability

DOI: 10.3233/CH-1987-7508

Citation: Clinical Hemorheology and Microcirculation, vol. 7, no. 5, pp. 715-722, 1987

Authors: e Silva, J. Martins

Article Type: Abstract

DOI: 10.3233/CH-1987-7509

Citation: Clinical Hemorheology and Microcirculation, vol. 7, no. 5, pp. 723-742, 1987