Technology and Health Care - Volume 29, issue S1

Authors: Li, Yaling | Chandra, Thakur Prakash | Song, Xiong | Nie, Liangui | Liu, Maojun | Yi, Jiali | Zheng, Xia | Chu, Chun | Yang, Jun

Article Type: Research Article

Abstract: OBJECTIVE: We waimed to investigate whether H 2 S can relieve the myocardial fibrosis caused by doxorubicin through Keap1-Nrf2. METHODS: Sprague-Dawley (SD) rats were randomly divided into four groups: normal control group (Control); DOX model group (DOX); H 2 S intervention model group (DOX+H 2 S); H 2 S control group (H 2 S). DOX and DOX+H 2 S group were injected with doxorubicin (3.0 mg/kg/time) intraperitoneally. Both of the Control group and H 2 …S groups were given normal saline in equal volume, 2 weeks later, DOX+H 2 S and H 2 S group were controlled with NaHS (56 μ mol/kg/d) through the abdominal cavity, while the Control and DOX group were injected with normal saline of the same dosage intraperitoneally. RESULTS: Myocardial injury and myocardial cell apoptosis were significantly increased, the H 2 S content in myocardial tissue was remarkably down-regulated, the expression levels of MDA, Keap1, caspase-3, caspase-9, TNF-α , IL1β , MMPs and TIMP-1 in rat myocardial tissue was significantly up-regulated (P < 0.05), and the expression levels of GSH, NQO1, Bcl-2 were down-regulated compared with those of control group. The above results can be reversed by the DOX+H 2 S group. There is no statistically significant difference between the Control group and the H 2 S control group. CONCLUSIONS: These results suggest that H 2 S can improve DOX-induced myocardial fibrosis in rats, and the keap1/Nrf2 signaling pathway, oxidative stress, inflammation, and apoptosis may be involved in the mechanism. Show more

Keywords: Hydrogen sulfide, doxorubicin, myocardial fibrosis, keap1/Nrf2, apoptosis

DOI: 10.3233/THC-218020

Citation: Technology and Health Care, vol. 29, no. S1, pp. 195-209, 2021

Authors: Chiang, Hsien-Wen | Wu, Re-Wen | Yin, Tsung-Cheng | Li, Jung-Hui | Wang, Yue-Sheng | Lin, Li-Han

Article Type: Research Article

Abstract: BACKGROUND: The purpose of this work was to evaluate orthopedic surgeons’ exposure to occupational radiation doses from scattering using a mobile flat panel C-arm X-ray machine at different standing positions during an intraoperative pedicle screw implantation. OBJECTIVE: Evaluate the radiation dose received by medical staff, by applying flat X-ray machine in surgical room during an intraoperative pedicle screw implantation. METHODS: A mobile flat-panel C-arm X-ray machine at a dedicated orthopedic operating room was used to image an anthropomorphic female phantom which was set in a prone position on the operating table. The X-ray …was projected horizontally, and 1 minute continuous fluoroscopy was used for lumbar spine and thoracolumbar spine during pedicle screw implantation. Scattering radiation doses to orthopedic surgeons were measured at different standing positions and body heights (50, 100, 150 cm above the ground) with and without limited collimations. RESULTS: The dose area product (DAP) in this experiment is normalized as 343 μ Gy⋅ m 2 . In the four areas, the lowest scattered radiation measured by DF is 11.2 vs. 0.7 μ Sv, outside and inside the lead suit, respectively, with or without restricted field, 150 cm above the ground, and the lowest scattered radiation dose inside the lead suit. It is 1.3 vs. 0.5 μ Sv. Comparing the highest dose of the TF at with the lowest dose of the DF, the average result is 73.7 vs. 11.1 μ Sv, P < 0.05. CONCLUSIONS: Using a mobile flat-panel C-arm X-ray machine during a pedicle screw implantation, the minimum scattering radiation to surgeons was found to be at the terminal DF area based on the analysis of the scattering doses orthopedic surgeons were exposed to. Show more

Keywords: Fluoroscopy, pedicle screw insertion, effective dose, scattered radiation

DOI: 10.3233/THC-218021

Citation: Technology and Health Care, vol. 29, no. S1, pp. 211-219, 2021

Authors: Niu, Junlong | Qin, Xiansheng | Bai, Jing | Li, Haiyan

Article Type: Research Article

Abstract: BACKGROUND: Nowadays, the total knee arthroplasty (TKA) technique plays an important role in surgical treatment for patients with severe knee osteoarthritis (OA). However, there are still several key issues such as promotion of osteotomy accuracy and prosthesis matching degree that need to be addressed. OBJECTIVE: It is significant to construct an accurate three-dimensional (3D) geometric anatomy structure model of subject-specific human knee joint with major bone and soft tissue structures, which greatly contributes to obtaining personalized osteotomy guide plate and suitable size of prosthesis. METHODS: Considering different soft tissue structures, magnetic resonance imaging …(MRI) scanning sequences involving two-dimensional (2D) spin echo (SE) sequence T1 weighted image (T1WI) and 3D SE sequence T2 weighted image (T2WI) fat suppression (FS) are selected. A 3D modeling methodology based on computed tomography (CT) and two sets of MRI images is proposed. RESULTS: According to the proposed methods of image segmentation and 3D model registration, a novel 3D knee joint model with high accuracy is finally constructed. Furthermore, remeshing is used to optimize the established model by adjusting the relevant parameters. CONCLUSIONS: The modeling results demonstrate that reconstruction and optimization model of 3D knee joint can clearly and accurately reflect the key characteristics, including anatomical structure and geometric morphology for each component. Show more

Keywords: 3D model reconstruction, human knee joint, 3D model registration, geometric model optimization, CT and MRI images

DOI: 10.3233/THC-218022

Citation: Technology and Health Care, vol. 29, no. S1, pp. 221-238, 2021

Authors: Wang, Qian | Du, Lijing | Hong, Jiana | Chen, Zhenlin | Liu, Huijian | Li, Shasha | Xiao, Xue | Yan, Shikai

Article Type: Research Article

Abstract: BACKGROUND: Shanmei Capsule is a famous preparation in China. However, the related mechanism of Shanmei Capsule against hyperlipidemia has yet to be revealed. OBJECTIVE: To elucidate underlying mechanism of Shanmei Capsule against hyperlipidemia through network pharmacology approach and molecular docking. METHODS: Active ingredients, targets of Shanmei Capsule as well as targets for hyperlipidemia were screened based on database. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment were performed via Database for Annotation, Visualization, and Integrated Discovery (DAVID) 6.8 database. Ingredient-target-disease-pathway network was visualized utilizing Cytoscape …software and molecular docking was performed by Autodock Vina. RESULTS: Seventeen active ingredients in Shanmei Capsule were screened out with a closely connection with 34 hyperlipidemia-related targets. GO analysis revealed 40 biological processes, 5 cellular components and 29 molecular functions. A total of 15 signal pathways were enriched by KEGG pathway enrichment analysis. The docking results indicated that the binding activities of key ingredients for PPAR-α are equivalent to that of the positive drug lifibrate. CONCLUSIONS: The possible molecular mechanism mainly involved PPAR signaling pathway, Bile secretion and TNF signaling pathway via acting on MAPK8, PPARγ , MMP9, PPARα , FABP4 and NOS2 targets. Show more

Keywords: Shanmei Capsule, hyperlipidemia, network pharmacology, molecular docking

DOI: 10.3233/THC-218023

Citation: Technology and Health Care, vol. 29, no. S1, pp. 239-256, 2021

Authors: Wang, Panpan | Jing, Chenxi | Yu, Pei | Lu, Meng | Xu, Xiaobo | Pei, Qinglan | Yan, Fengmei

Article Type: Research Article

Abstract: BACKGROUND: Bupropion, one of the dual norepinephrine and dopamine reuptake inhibitors (NDRIs), is an aminoketone derivative performed effect in improving cognitive function for depression. However, its therapeutic effect is unsatisfactory due to poor clinical response, and there are only few derivatives in pre-clinical settings. OBJECTIVE: This work attempted to elucidate the essential structural features for the activity and designed a series of novel derivatives with good inhibitive ability, pharmacokinetic and medicinal chemistry properties. METHODS: The field-based QSAR of aminoketone derivatives of two targets were established based on docking poses, and the essential structural …properties for designing novel compounds were supplied by comparing contour maps. RESULTS: The selected two models performed good predictability and reliability with R 2 of 0.8479 and 0.8040 for training set, Q 2 of 0.7352 and 0.6266 for test set respectively, and the designed 29 novel derivatives performed no less than the highest active compound with good ADME/T pharmacokinetic properties and medicinal chemistry friendliness. CONCLUSIONS: Bulky groups in R 1 , bulky groups with weak hydrophobicity in R 3 , and potent hydrophobic substituted group with electronegative in R 2 from contour maps provided important insights for assessing and designing 29 novel NDRIs, which were considered as candidates for cognitive dysfunction with depression or other related neurodegenerative disorders. Show more

Keywords: Cognitive dysfunctions, field-based QSAR, drug design, pharmacokinetic properties

DOI: 10.3233/THC-218024

Citation: Technology and Health Care, vol. 29, no. S1, pp. 257-273, 2021

Authors: Li, Yantao

Article Type: Research Article

Abstract: BACKGROUND AND OBJECTIVE: Orienteering, which is one of the popular physical educations in the world, is an emerging sport integrating knowledge, competition, fun, and collaborative attributes. Although it started late in China, it has developed rapidly in recent years in most places except the northeast and northwest parts of the country. METHODS: In order to accelerate the development of orienteering in the northeast, given the climate and social characteristics of this area, we built a four-in-one orienteering development model including a theory course, a social component, a team, and events based on the longtime practice of …Harbin Engineering University. RESULTS: The research results have practical reference significance for orienteering at universities in China, as well as at universities and commercial clubs in other areas of the world. Show more

Keywords: Orienteering, physical education, practical research, universities of northeast China

DOI: 10.3233/THC-218025

Citation: Technology and Health Care, vol. 29, no. S1, pp. 275-286, 2021

Authors: Zhou, Zhiming | Huang, Haihui | Liang, Yong

Article Type: Research Article

Abstract: BACKGROUND: In genome research, it is particularly important to identify molecular biomarkers or signaling pathways related to phenotypes. Logistic regression model is a powerful discrimination method that can offer a clear statistical explanation and obtain the classification probability of classification label information. However, it is unable to fulfill biomarker selection. OBJECTIVE: The aim of this paper is to give the model efficient gene selection capability. METHODS: In this paper, we propose a new penalized logsum network-based regularization logistic regression model for gene selection and cancer classification. RESULTS: Experimental results on …simulated data sets show that our method is effective in the analysis of high-dimensional data. For a large data set, the proposed method has achieved 89.66% (training) and 90.02% (testing) AUC performances, which are, on average, 5.17% (training) and 4.49% (testing) better than mainstream methods. CONCLUSIONS: The proposed method can be considered a promising tool for gene selection and cancer classification of high-dimensional biological data. Show more

Keywords: Regularization, gene selection, log-sum penalty, network-based knowledge

DOI: 10.3233/THC-218026

Citation: Technology and Health Care, vol. 29, no. S1, pp. 287-295, 2021

Authors: Chen, Xiaohui | Sun, Wenbo | Xu, Dan | Ma, Jiaojiao | Xiao, Feng | Xu, Haibo

Article Type: Research Article

Abstract: BACKGROUND: Computed tomography (CT) imaging combined with artificial intelligence is important in the diagnosis and prognosis of lung diseases. OBJECTIVE: This study aimed to investigate temporal changes of quantitative CT findings in patients with COVID-19 in three clinic types, including moderate, severe, and non-survivors, and to predict severe cases in the early stage from the results. METHODS: One hundred and two patients with confirmed COVID-19 were included in this study. Based on the time interval between onset of symptoms and the CT scan, four stages were defined in this study: Stage-1 (0 ∼ …7 days); Stage-2 (8 ∼ 14 days); Stage-3 (15 ∼ 21days); Stage-4 (> 21 days). Eight parameters, the infection volume and percentage of the whole lung in four different Hounsfield (HU) ranges, ((- , - 750), [- 750, - 300), [- 300, 50) and [50, + )), were calculated and compared between different groups. RESULTS: The infection volume and percentage of four HU ranges peaked in Stage-2. The highest proportion of HU [- 750, 50) was found in the infected regions in non-survivors among three groups. CONCLUSIONS: The findings indicate rapid deterioration in the first week since the onset of symptoms in non-survivors. H higher proportion of HU [- 750, 50) in the lesion area might be a potential bio-marker for poor prognosis in patients with COVID-19. Show more

Keywords: COVID-19, quantitative CT parameters, temporal changes, early detection

DOI: 10.3233/THC-218027

Citation: Technology and Health Care, vol. 29, no. S1, pp. 297-309, 2021

Authors: Bao, Xinyu | Wang, Yan | Zhang, Song | Yang, Lin | Liu, Guoli | Yang, Yimin | Li, Xuwen | Hao, Dongmei | Chen, Aiqing | Liu, Xiaohong | Shao, Jing

Article Type: Research Article

Abstract: BACKGROUND: Fetal weight is one of the important indicators for judging whether fetal growth and development are normal. Fetal weight exceeding the normal range may lead to poor delivery outcomes. OBJECTIVE: We aimed to establish a personalized fetal growth curve in order to effectively monitor fetal growth during pregnancy. Fetal weight can be monitored while fetal growth and development are assessed. METHODS: This study retrospectively analyzed the birth weight and ultrasound database of 3,093 newborns delivered at normal term. The personalized fetal growth curve model was generated based on the birth weight formula …established by Gardosi combined with the proportional weight equation. RESULTS: (1) The average birth weight of the single fetus at normal term was 3,457g. (2) According to the regression results of the proportion of fetal weight in full-term pregnancy and gestational week, the proportional weight equation is Weight% = 500.9 - 51.60GA + 1.727GA 2 - 0.01718GA 3 (GA is gestational week), R 2 is 98%, P < 0.001. CONCLUSIONS: In this study, the normal birth weight of newborns and normal range of fetal weight can be estimated by using the personalized fetal growth curve model. Show more

Keywords: Fetal weight, fetal growth curve, birth weight, proportional weight equation, normal range

DOI: 10.3233/THC-218028

Citation: Technology and Health Care, vol. 29, no. S1, pp. 311-317, 2021

Authors: Bang, Sang Kwang | Seong, Ki Woong | Kim, Myoung Nam | Lee, Jyung Hyun

Article Type: Research Article

Abstract: BACKGOROUND AND OBJECTIVE: Cardiovascular disorders are increasing because of poor eating habits, excessive drinking, and lack of exercise. Some of the typical cardiovascular surgical procedures utilize catheters. Catheter-based procedures require the surgeons to have extensive experience and high proficiency at performing vascular interventions. However, the learning period to acquire such proficiency is lengthy and the opportunities for practical training and mastery are insufficient. Therefore, due to insufficient skill, dangerous situations with damage or rupture of the patient’s blood vessels may occur, thereby increasing the risk of medical accidents. Hence, it is necessary to have experience and proficiency for performing …vascular interventions. Thus, it is necessary to develop a simulator to shorten learning time and reduce medical accidents. METHODS: In this study, we developed a position detection system for the simulator to use physical models to learn cardiovascular surgical intervention techniques. The developed system uses changes in the output values of a Hall sensor based on the position of a permanent magnet. RESULTS AND CONCLUSIONS: From the changing output values, the distance calculation equation is derived, and the position of the permanent magnet is effectively estimated from the calculations. The performance of the position detecting system was tested, and the results proved that the system could be sufficiently used as a simulator. Show more

Keywords: Permanent magnet, hall sensor, hall effect, position detection, medical simulator

DOI: 10.3233/THC-218029

Citation: Technology and Health Care, vol. 29, no. S1, pp. 319-326, 2021