NeuroRehabilitation - Volume 42, issue 4

Authors: Li, Yanwei | Wen, Yibo | He, Xiangfei | Li, Yunlong | Wu, Junwei | Feng, Jinjin | Wang, Qingwei | Wen, Jianguo

Article Type: Research Article

Abstract: BACKGROUND: Neurogenic bladder (NB) is a common pediatric urological disease caused by a variety of neurological pathologies. Clean intermittent catheterization (CIC) has been the preferred method to empty bladder. OBJECTIVE: To investigate the effect of CIC on preserving bladder and upper urinary tract function in infants less than 1 year old with NB. METHODS: A retrospective analysis was conducted on 76 infants with NB. Patients were divided into two groups according to treatment initiation: the early CIC group (ECG) (<1 year old) and the late CIC group (LCG) (>3 years old). RESULTS: Bladder compliance (BC), …safe bladder capacity (SBC) and maximum cystometric capacity (MCC) were significantly higher in the ECG than those in the LCG at 6 years of follow-up respectively (P  <  0.05). The frequencies of vesicoureteral reflux (VUR) and urinary tract infection (UTI) in the ECG were significantly lower than those in the LCG (P  <  0.05) at 6 years of follow-up. Two and nine patients exhibited mild renal damage in the ECG and LCG, respectively, resulting in a significant difference (P  <  0.05) at 6 years of follow-up. CONCLUSION: Early CIC plays an important role in preserving bladder function and preventing UTI and renal deterioration in infants with NB, especially in the first year of life. Show more

Keywords: Neurogenic bladder, clean intermittent catheterization, infants

DOI: 10.3233/NRE-172366

Citation: NeuroRehabilitation, vol. 42, no. 4, pp. 377-382, 2018

Authors: Himuro, Nobuaki | Mishima, Reiko | Seshimo, Takashi | Morishima, Toshibumi | Kosaki, Keisuke | Ibe, Shigeharu | Asagai, Yoshimi | Minematsu, Koji | Kurita, Kazuhiro | Okayasu, Tsutomu | Shimura, Tsukasa | Hoshino, Kotaro | Suzuki, Toshiro | Yanagizono, Taiichiro

Article Type: Research Article

Abstract: BACKGROUND: The prognosis for mobility function by Gross Motor Function Classification System (GMFCS) level is vital as a guide to rehabilitation for people with cerebral palsy. OBJECTIVE: This study sought to investigate change in mobility function and its causes in adults with cerebral palsy by GMFCS level. METHODS: We conducted a cross-sectional questionnaire study. RESULTS: A total of 386 participants (26 y 8 m, SD 5 y 10 m) with cerebral palsy were analyzed. Participant numbers by GMFCS level were: I (53), II (139), III (74) and IV (120). The median age of participants with peak …mobility function in GMFCS level III was younger than that in the other levels. 48% had experienced a decline in mobility. A Kaplan-Meier plot showed the risk of mobility decline increased in GMFCS level III; the hazard ratio was 1.97 (95% CI, 1.20–3.23) compared with level I. The frequently reported causes of mobility decline were changes in environment, and illness and injury in GMFCS level III, stiffness and deformity in level IV, and reduced physical activity in level II and III. CONCLUSIONS: Peak mobility function and mobility decline occurred at a younger age in GMFCS level III, with the cause of mobility decline differing by GMFCS level. Show more

Keywords: Cerebral palsy, mobility, gross motor function

DOI: 10.3233/NRE-172340

Citation: NeuroRehabilitation, vol. 42, no. 4, pp. 383-390, 2018

Authors: Raphaely Beer, Noa | Soroker, Nachum | Bornstein, Nathan M. | Katz-Leurer, Michal

Article Type: Research Article

Abstract: BACKGROUND: Autonomic disturbances are a common phenomenon in patients’ post-stroke, characterized by hypo function of the para-sympathetic and/or overactive sympathetic system. The impact of autonomic disturbances on physical therapy tasks during the rehabilitation period has not yet been assessed. OBJECTIVE: To describe the response of the cardiac autonomic nervous system during different tasks, among patients and age-matched healthy controls. METHODS: Nineteen patients in the subacute phase post first-ever ischemic stroke, and 16 controls. The Polar advanced heart rate monitor (RS800CX) was used to record RR intervals at rest, during paced breathing exercise, while performing different types …of muscle contractions, and during single and dual task conditions. RESULTS: RR intervals and heart-rate variability (HRV) parameters were significantly lower among patients post stroke, both at rest and during most of the activities tested. Among the control group a significant autonomic adaptation was seen in the form of reduced RR intervals and HRV during muscle contraction and a significant increase in these parameters during slow breathing, no significant changes were observed among patients post stroke. CONCLUSION: Patients post-stroke experience hyper sympathetic function at rest and less adaptive cardiac autonomic control during different activities, which all may have an impact on rehabilitation outcomes. Show more

Keywords: Stroke, cardiac autonomic nervous system, heart rate variability

DOI: 10.3233/NRE-172295

Citation: NeuroRehabilitation, vol. 42, no. 4, pp. 391-396, 2018

Authors: Pertab, Jon L. | Merkley, Tricia L. | Cramond, Alex J. | Cramond, Kelly | Paxton, Holly | Wu, Trevor

Article Type: Review Article

Abstract: BACKGROUND: Recent evidence suggests that autonomic nervous dysfunction may be one of many potential factors contributing to persisting post-concussion symptoms. OBJECTIVE: This is the first systematic review to explore the impact of concussion on multiple aspects of autonomic nervous system functioning. METHODS: The methods employed are in compliance with the American Academy of Neurology (AAN) and PRISMA standards. Embase, MEDLINE, PsychINFO, and Science Citation Index literature searches were performed using relevant indexing terms for articles published prior to the end of December 2016. Data extraction was performed by two independent groups, including study quality indicators to …determine potential risk for bias according to the 4-tiered classification scheme of the AAN. RESULTS: Thirty-six articles qualified for inclusion in the analysis. Only three studies (one Class II and two Class IV) did not identify anomalies in measures of ANS functioning in concussed populations. CONCLUSIONS: The evidence supports the conclusion that it is likely that concussion causes autonomic nervous system anomalies. An awareness of this relationship increases our understanding of the physical impact of concussion, partially explains the overlap of concussion symptoms with other medical conditions, presents opportunities for further research, and has the potential to powerfully inform treatment decisions. Show more

Keywords: Concussion, mild traumatic brain injury, post-concussion syndrome, autonomic dysfunction, orthostatic intolerance

DOI: 10.3233/NRE-172298

Citation: NeuroRehabilitation, vol. 42, no. 4, pp. 397-427, 2018

Authors: Villán-Villán, Mailin Adriana | Pérez-Rodríguez, Rodrigo | Martín, Cristina | Sánchez-González, Patricia | Soriano, Ignasi | Opisso, Eloy | Hernando, M. Elena | Tormos, José María | Medina, Josep | Gómez, Enrique J.

Article Type: Research Article

Abstract: BACKGROUND: The increasing number of patients with acquired brain injury and the current subjectivity of the conventional upper extremity (UE) assessment tests require new objective assessment techniques. OBJECTIVE: This research proposes a novel objective motor assessment (OMA) methodology based on the Fugl-Meyer assessment (FMA). The goals are to automatically calculate the objective scores (OSs) of FMA-UE movements (as well as a global OS) and to interpret the estimated OSs. METHODS: Fifteen patients participated in the study. The OMA algorithm was designed to detect small-scale variations in UE movements. The OSs for 14 FMA-UE movements and the …global OSs were automatically calculated using the algorithm and evaluated by 2 therapists. The interpretation of the global OSs was performed at 3 levels: by item, movement and globally. RESULTS: The global OSs calculated by our algorithm had a significant correlation with the therapists’ scores (0.783 and 0.938, p  <  0.01). All OSs for each movement were correlated with the scores given by the therapists. The correlation coefficient can reach values as high as 0.981 (p  <  0.01). CONCLUSIONS: We provide a new objective assessment tool for therapists to help them improve the diagnostic accuracy and to achieve a more personalized and potentially effective physical rehabilitation of brain injury patients. Show more

Keywords: Physical and rehabilitation medicine, Fugl-Meyer assessment upper extremity, brain injury, stroke, objective assessment tool, algorithm, kinematic analysis

DOI: 10.3233/NRE-172315

Citation: NeuroRehabilitation, vol. 42, no. 4, pp. 429-439, 2018

Authors: Aida, Jared | Chau, Brian | Dunn, Justin

Article Type: Research Article

Abstract: BACKGROUND: Traumatic brain injury (TBI) is a common cause of morbidity and mortality in the United States with its sequelae often affecting individuals long after the initial injury. Innovations in virtual reality (VR) technology may offer potential therapy options in the recovery from such injuries. However, there is currently no consensus regarding the efficacy of VR in the setting of TBI rehabilitation. OBJECTIVE: The aim of this review is to evaluate and summarize the current literature regarding immersive VR in the rehabilitation of those with TBI. METHODS: A comprehensive literature search was conducted utilizing PubMed, Google …Scholar, and the Cochrane Review using the search terms “virtual reality,” “traumatic brain injury,” “brain injury,” and “immersive.” RESULTS: A total of 11 studies were evaluated. These were primarily of low-level evidence, with the exception of two randomized, controlled trials. 10 of 11 studies demonstrated improvement with VR therapy. VR was most frequently used to address gait or cognitive deficits. CONCLUSIONS: While the current literature generally offers support for the use of VR in TBI recovery, there is a paucity of strong evidence to support its widespread use. The increasing availability of immersive VR technology offers the potential for engaging therapy in TBI rehabilitation, but its utility remains uncertain given the limited studies available at this time. Show more

Keywords: Virtual reality, traumatic brain injury, therapy, rehabilitation

DOI: 10.3233/NRE-172361

Citation: NeuroRehabilitation, vol. 42, no. 4, pp. 441-448, 2018

Authors: Boselli, Mirella | Aquilani, Roberto | Maestri, Roberto | Achilli, Maria Pia | Arrigoni, Nadia | Pasini, Evasio | Condino, Anna Maria | Boschi, Federica | Dossena, Maurizia | Buonocore, Daniela | Verri, Manuela

Article Type: Research Article

Abstract: BACKGROUND: Systemic inflammation and its impact on rehabilitation for patients with non-traumatic haemorrhagic injury (HBI) sequelae has not yet been adequately documented. OBJECTIVE AND METHODS: We therefore considered 31 patients with HBI, to determine the serum levels of inflammatory markers (C-Reactive Protein, CRP and or interleukine-6, IL-6) to establish their impact on functional status (Functional Independence Measure, FIM: 18 indicating the worst performance and 126, a normal score). RESULTS: The results showed an inflammation prevalence (CRP >0.5 mg/dl and/or IL 6 >7 pg/ml) of 74.2% at admission to Rehab. FIM reduction was more pronounced in inflamed compared …to non-inflamed subjects (p  <  0.05) and significantly correlated with blood variables sensitive to inflammation, such as alpha 1 globulin (r  = – 0.565) and neutrophil/ lymphocyte ratio (r  = – 0.52), CRP (r  = – 0.365). At discharge from Rehab, the inflammation rate diminished. Inflamed patients showed similar gains in FIM score as their controls. In the entire population, the FIM gain was significantly associated with a gain in serum albumin, only (r  = +0.56). CONCLUSIONS: We conclude that systemic inflammation is prevalent in HBI patients and contributes to reduce patient functional status. However, during the Rehab stage, inflammation does not hinder the improvement rate of functional capacity. Show more

Keywords: Haemorrhagic stroke, inflammation, rehabilitation, functional recovery rate

DOI: 10.3233/NRE-172362

Citation: NeuroRehabilitation, vol. 42, no. 4, pp. 449-456, 2018

Authors: Park, Ji-Su | Oh, Dong-Hwan | Hwang, Na-Kyoung | Lee, Jung-Hoon

Article Type: Research Article

Abstract: BACKGROUND: Neuromuscular electrical stimulation has been used to improve swallowing function in neurologic patients with dysphagia, but its effect on patients with dysphagia and Parkinson’s disease remains unclear. OBJECTIVES: This study aimed to identify the effect of effortful swallowing combined with neuromuscular electrical stimulation as a novel treatment approach in dysphagic patients with Parkinson’s disease. METHODS: Participants were randomly allocated to an experimental group (n  = 9) or a placebo group (n  = 9). The experimental group simultaneously received neuromuscular electrical stimulation with effortful swallowing, while the placebo group received sham neuromuscular electrical stimulation with effortful swallowing. All …participants received the treatment for 30 min/day at five sessions per week for 4 weeks. Both groups also received the same conventional dysphagia therapy. RESULTS: The experimental group showed significant differences in horizontal movement (p  = 0.038) and vertical movement (p  = 0.042) compared to the placebo group, but showed no significant differences in the oral (p  = 0.648) or pharyngeal phase (p  = 0.329) of the Videofluoroscopic Dysphagia Scale compared to the placebo group, except for the Penetration-Aspiration Scale (p  = 0.039). CONCLUSIONS: We demonstrated that neuromuscular electrical stimulation applied to the infrahyoid region combined with effortful swallowing effectively increased hyoid bone movement and reduced aspiration in dysphagic patients with Parkinson’s disease. Show more

Keywords: Dysphagia, Parkinson’s disease, swallowing, neuromuscular electrical stimulation

DOI: 10.3233/NRE-172306

Citation: NeuroRehabilitation, vol. 42, no. 4, pp. 457-463, 2018

Authors: Spagnuolo, Gessyca | Faria, Christina D.C.M. | da Silva, Bruna Adriana | Ovando, Angélica Cristiane | Gomes-Osman, Joyce | Swarowsky, Alessandra

Article Type: Research Article

Abstract: BACKGROUND: The Timed up and go test (TUG), the Five times sit-to-stand test (FTSTS) and the Bed Mobility test (BMT) are widely used in clinical practice for Parkinson Disease (PD). However, no reported studies have evaluated the responsiveness to group physical therapy intervention (GPTI). OBJECTIVE: To verify if TUG, FTSTS and BMT were responsive to GPTI. METHODS: Thirty individuals with PD were assessed prior to and after an 8-week evidence-based GPTI. Paired t test was used to determine statistically significant change pre-and post-intervention. Internal responsiveness (IR) was classified with the standardized response mean (SRM). A 5-point …Likert scale assessed self-perceived performance by the subjects after the intervention. Analysis of the receiver operating characteristic (ROC) curve was used to determine the accuracy and cut-off scores for identifying participants who had shown improvement. RESULTS: GPTI was efficient in improving real (p ≤0.001) and self-perceived mobility performance in all measures. All tests were responsive to changes: the IR varied from medium to high (SRM = 0.7–1.5); the cut-off point for TUG test was >2.2 s, for FTSTS test was >2.5 s and for BM test >1.4 s. CONCLUSIONS: The TUG, FTSTS and BMT were responsive to the GPTI and accurately detected meaningful clinical changes. Our results provide an important information about the clinical application of these tests in PD individuals. Show more

Keywords: Parkinson disease, mobility, responsiveness, physiotherapy

DOI: 10.3233/NRE-172379

Citation: NeuroRehabilitation, vol. 42, no. 4, pp. 465-472, 2018

Authors: de Melo, Gileno Edu Lameira | Kleiner, Ana Francisca Rozin | Lopes, Jamile Benite Palma | Dumont, Arislander Jonathan Lopes | Lazzari, Roberta Delasta | Galli, Manuela | Oliveira, Claudia Santos

Article Type: Research Article

Abstract: OBJECTIVE: To evaluate the effects of gait training with virtual reality (VR) on walking distance and physical fitness in individuals with Parkinson’s Disease (PD). METHODS: Thirty-seven individuals with PD participated in this prospective, randomized, controlled clinical trial. They were randomly allocated to a control group submitted to conventional training (n  = 12), a treadmill group submitted to gait training on a treadmill (n  = 13) and a VR group submitted to gait training using the XboxTM (n  = 12). Clinical measures, gait variables and the Six-Minute Walk Test (6MWT) were evaluated: pre-intervention, after one intervention session, post-intervention and follow up (30 …days after intervention). RESULTS: The VR and treadmill groups travelled longer distances on the 6MWT and had faster gait speed in comparison to the control group. The VR and treadmill groups demonstrated an increase in pre-6MWT HR. The VR group had more intense HR after the first session and throughout training, but these gains were not maintained at the follow-up. CONCLUSION: The present findings demonstrate that gait training with a VR program is as effective as treadmill training with regard to gains in walking distance and improvements in temporal gait variables in individuals with PD. Show more

Keywords: Virtual reality, gait training, Parkinson’s disease, physical fitness, inertial sensors

DOI: 10.3233/NRE-172355

Citation: NeuroRehabilitation, vol. 42, no. 4, pp. 473-480, 2018

Authors: Hwang, Jongseok | Shin, Yongil | Park, Ji-ho | Cha, Young Joo | You, Joshua (Sung) H.

Article Type: Research Article

Abstract: BACKGROUND: The robotic-assisted gait training (RAGT) system has gained recognition as an innovative, effective paradigm to improve functional ambulation and activities of daily living in spinal cord injury and stroke. However, the effects of the Walkbot robotic-assisted gait training system with a specialized hip-knee-ankle actuator have never been examined in the paraplegia and quadriplegia population. OBJECTIVE: The aim of this study was to determine the long-term effects of Walkbot training on clinical for hips and knee stiffness in individuals with paraplegia or quadriplegia. METHODS: Nine adults with subacute or chronic paraplegia resulting from spinal cord injury …or quadriplegia resulting from cerebral vascular accident (CVA) and/or hypoxia underwent progressive conventional gait retraining combined with the Walkbot RAGT for 5 days/week over an average of 43 sessions for 8 weeks. Clinical outcomes were measured with the Functional Ambulation Category (FAC), Modified Rankin Scale (MRS), Korean version of the Modified Barthel Index (K-MBI), Modified Ashworth Scale (MAS). Kinetic and kinematic data were collected via a built-in Walkbot program. RESULTS: Wilcoxon signed-rank tests showed significant positive intervention effects on K-MBI, maximal hip flexion and extension, maximal knee flexion, active torque in the knee joint, resistive torque, and stiffness in the hip joint (P  <  0.05). These findings suggest that the Walkbot RAGT was effective for improving knee and hip kinematics and the active knee joint moment while decreasing hip resistive force. These improvements were associated with functional recovery in gait, balance, mobility and daily activities. CONCLUSIONS: These findings suggest that the Walkbot RAGT was effective for improving knee and hip kinematics and the active knee joint moment while decreasing hip resistive force. This is the first clinical evidence for intensive, long-term effects of the Walkbot RAGT on active or resistive moments and stiffness associated with spasticity and functional mobility in individuals with subacute or chronic paraplegia or quadriplegia who had reached a plateau in motor recovery after conventional therapy. Show more

Keywords: Paraplegia, quadriplegia, robotic-assisted gait training, Walkbot, stiffness, gait, neurorehabilitation

DOI: 10.3233/NRE-172226

Citation: NeuroRehabilitation, vol. 42, no. 4, pp. 481-489, 2018

Authors: In, Taesung | Jung, Kyoungsim | Lee, Min-Goo | Cho, Hwi-young

Article Type: Research Article

Abstract: OBJECTIVES: This study aimed to investigate the effects of whole-body vibration (WBV) training on ankle spasticity, balance, and walking ability in patients with incomplete spinal cord injury (iSCI) at cervical level. METHODS: Twenty-eight patients with cervical iSCI were randomly assigned to WBV (n  = 14) or control group (n  = 14). WBV group received WBV training, while control group was treated with placebo-treatment. All interventions were given for 20-min, twice a day, 5-days a week for 8-weeks. The spasticity of ankle plantar-flexors was assessed by estimating passive resistive force using a hand-held dynamometer. Balance was analyzed based on postural sway …length (PSL) using a force plate. Timed-Up and Go test (TUG) and 10 m-Walk Test (10MWT) were used to assess walking ability. RESULTS: Both groups showed significant improvements in spasticity, balance and walking ability. Also, the significant differences between two groups were demonstrated in the outcomes of spasticity (3.0±1.7 vs 0.9±1.2), PSL (6.4±1.2 vs 3.2±0.9 with eyes-open, and 15.1±10.9 vs 7.4±4.3 with eyes-closed), TUG (2.3±1.3 vs 1.0±1.0), and 10MWT (3.5±2.3 vs 1.3±1.4). CONCLUSIONS: WBV may be a safe and effective intervention to improve spasticity, balance and walking ability in individuals with cervical iSCI. Thus, WBV may be used to improve these symptoms in clinics. Show more

Keywords: Balance, incomplete spinal cord injury, whole body vibration

DOI: 10.3233/NRE-172333

Citation: NeuroRehabilitation, vol. 42, no. 4, pp. 491-497, 2018

Authors: Vincent-Onabajo, Grace | Joseph, Emmanuel | Musa, Hadiza Yakubu

Article Type: Research Article

Abstract: BACKGROUND: Functional independence is often compromised after stroke and its restoration is one of the goals of stroke rehabilitation. OBJECTIVE: This study assessed the impact of balance on functional independence after stroke. METHODS: Ninety-five stroke patients undergoing physical rehabilitation at two health institutions in Nigeria participated in the study. Balance and functional independence were respectively assessed with the Berg Balance Scale and the Barthel Index. Binary logistic regression analysis was conducted to examine the independent impact of balance on functional independence while controlling for participants’ age, sex, side of hemiparesis and post-stroke duration. RESULTS: …Mean±SD age of the participants was 58.4±13.1 years and females were more (f = 48; %  = 50.5). The regression model from the binary regression analysis explained 73.2% (Nagelkerke R2  = 0.732) of the variance in functional independence. Good balance function was found to independently and significantly (P  <  0.01) increase the likelihood of being functionally independent after stroke (Odds ratio = 1.33; 95% CI = 1.11 to 1.58). CONCLUSION: The goal of attaining functional independence after stroke may depend to a significant extent on good balance function irrespective of the stroke survivor’s age, sex and post-stroke duration. Show more

Keywords: Activities of daily living, balance, stroke, functional independence, Nigeria

DOI: 10.3233/NRE-172305

Citation: NeuroRehabilitation, vol. 42, no. 4, pp. 499-504, 2018

Authors: Song, SunHae | Park, JungHee | Song, GyuDong | Lee, SeulGi | Jo, YoHan | Jin, MinKyung | Lee, DongGeon | Jung, SunHye | Hong, SoungKyun | Lee, SeungHoo | Pyo, SeungHyeon | Lee, GyuChang

Article Type: Research Article

Abstract: BACKGROUND: Stroke survivors show “foot drop”, dragging their toes on the ground in the swing phase of gait. Ineffective ankle dorsiflexion may result in an abnormal gait pattern. OBJECTIVE: The purpose of this study was to investigate the effect of ankle Thera-Band® use on gait patterns in stroke survivors. METHODS: Gait data were collected in eight subjects who had had strokes using gait analysis system, both with and without the Thera-Band® . The following dependent variables of gait parameters were analyzed: velocity, cadence, step length, stride length, single support time, and double support time. …RESULTS: There were significant improvements in gait velocity, cadence, stride length, and double support time in those who used the Thera-Band® compared to those who did not (p  <  0.05). However, there were no significant differences in step length or single support time (p  >  0.05). CONCLUSIONS: The results show that ankle Thera-Band® use may have a positive effect in improving gait parameters by increasing the ankle stability in stroke survivors with foot drop. Its usefulness in the rehabilitation of foot drop in stroke survivors needs to be further investigated. Show more

Keywords: Stroke survivor, foot drop, Thera-Band®

DOI: 10.3233/NRE-172338

Citation: NeuroRehabilitation, vol. 42, no. 4, pp. 505-510, 2018