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Price: EUR 185.00Authors: Tsushima, N. | Kato, T. | Matsuda, T. | Matsuo, H. | Hiramori, K.
Article Type: Research Article
Abstract: Macro and micro-hemorheological analyses on thirteen kinds of cardiovascular and related diseases and healthy young and old controls, 1.102 cases, were carried out together with analyses of hemorheology-related factors. Whole blood viscosity at shear rate of 94.5 and 0.376 s−1 and plasma viscosity at shear rate of 94.5s−1 was measured respectively by Low Shear-30. Whole blood at both shear rates and plasma viscosity in valvular diseases showed significant decrease and those of all the other diseases did not show significant change compared to those of young and old control. Whole blood Passage time measured through Nuclepore membrane with …pore size of 5 µm were prolonged significantly in all these diseases with except of valvular diseases. Fibrinogen revealed significant increase in all these diseases. Macrohemorheology presented by whole blood and plasma viscosity in cardiovascular diseases and old control except valvular diseases showed no significant changes, while microhemorheology presented by whole blood passage time of them demonstrated significant abnormalities. The direction of change in macro and microhemorheology in valvular disease was quite different from other that observed in cardiovascular diseases. Show more
Keywords: cardiovascular diseases, valvular disease, whole blood viscosity, plasma viscosity, whole blood passage time
DOI: 10.3233/CH-1990-10411
Citation: Clinical Hemorheology and Microcirculation, vol. 10, no. 4, pp. 435-448, 1990
Authors: Caimi, Gregorio | Serra, Antonio | Catania, Anna | D’Asaro, Salvatrice | Lo Presti, Rosalia | Sarno, Antonio
Article Type: Research Article
Abstract: We evaluated the microrheological determinants and the red cell membrane individual membrane phospholipids in subjects with VAD. Our study included four groups of patients. In the first group, we evaluated the membrane lipid fluidity using the ghosts marked with DPH. In the second group, the erythrocyte membrane fluidity was employed marking intact red cells with pyrene. In the third group, the membrane fluidity transverse gradient was evaluated marking intact red cells with fatty acid fluorescent probes: 2-AP, 6-AS, 9-AS, 12-AS. In the fourth group we evaluated the red cell membrane phospholipids and the Iex/Im ratio. Examining the first group, it …is evident that the fluorescence polarization degree does not discriminate normals from this group. Examining the second group, it is evident that the Iex/Im ratio distinguishes normals from this group. Examining the third group, it is evident that the degree of polarization obtained with each fatty acid fluorescent probe does not distinguish normals from this group. Examining the fourth group, it is evident that no significant difference is present between normals and this group regarding erythrocyte individual phospholipids; a slight significant correlation is evident only between the Iex/Im ratio and phosphatidylethanolamine. Show more
Keywords: vascular atherosclerotic disease, microrheological determinants, erythrocyte membrane phospholipids
DOI: 10.3233/CH-1990-10412
Citation: Clinical Hemorheology and Microcirculation, vol. 10, no. 4, pp. 449-458, 1990
Article Type: Announcement
DOI: 10.3233/CH-1990-10413
Citation: Clinical Hemorheology and Microcirculation, vol. 10, no. 4, pp. 459-461, 1990
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