Hemorheological analyses on cardiovascular diseases
Issue title: The Seventh International Congress of Biorheology. Part II, Clinical Hemorheology. Held at Palais des Congrès, Nancy, France, 18–23 June 1989
Guest editors: Alfred L. Copley and Jean-François Stoltz
Affiliations: [a] Department of Internal Medicine, National Cardiovascular Center, Suita, Osaka, Japan | [b] Department of Bioengineering, National Cardiovascular Center, Suita, Osaka, Japan
Note: [] Accepted by: Editor L. Dintenfass
Abstract: Macro and micro-hemorheological analyses on thirteen kinds of cardiovascular and related diseases and healthy young and old controls, 1.102 cases, were carried out together with analyses of hemorheology-related factors. Whole blood viscosity at shear rate of 94.5 and 0.376 s−1 and plasma viscosity at shear rate of 94.5s−1 was measured respectively by Low Shear-30. Whole blood at both shear rates and plasma viscosity in valvular diseases showed significant decrease and those of all the other diseases did not show significant change compared to those of young and old control. Whole blood Passage time measured through Nuclepore membrane with pore size of 5 µm were prolonged significantly in all these diseases with except of valvular diseases. Fibrinogen revealed significant increase in all these diseases. Macrohemorheology presented by whole blood and plasma viscosity in cardiovascular diseases and old control except valvular diseases showed no significant changes, while microhemorheology presented by whole blood passage time of them demonstrated significant abnormalities. The direction of change in macro and microhemorheology in valvular disease was quite different from other that observed in cardiovascular diseases.
