Bio-Medical Materials and Engineering - Volume 26, issue s1

Authors: Shi, Yu | Yan, Guozheng | Zhu, Bingquan | Liu, Gang

Article Type: Research Article

Abstract: Wireless power transmission (WPT) technology can solve the energy shortage problem of the video capsule endoscope (VCE) powered by button batteries, but the fixed platform limited its clinical application. This paper presents a portable WPT system for VCE. Besides portability, power transfer efficiency and stability are considered as the main indexes of optimization design of the system, which consists of the transmitting coil structure, portable control box, operating frequency, magnetic core and winding of receiving coil. Upon the above principles, the correlation parameters are measured, compared and chosen. Finally, through experiments on the platform, the methods are tested and evaluated. …In the gastrointestinal tract of small pig, the VCE is supplied with sufficient energy by the WPT system, and the energy conversion efficiency is 2.8%. The video obtained is clear with a resolution of 320×240 and a frame rate of 30 frames per second. The experiments verify the feasibility of design scheme, and further improvement direction is discussed. Show more

Keywords: Portable wireless power transmission, video capsule endoscope, resonant circuit, frequency stability

DOI: 10.3233/BME-151472

Citation: Bio-Medical Materials and Engineering, vol. 26, no. s1, pp. S1721-S1730, 2015

Authors: Jia, Guifeng | Yang, Pan | Zhou, Jie | Zhang, Hengyi | Lin, Chengyu | Chen, Jin | Cai, Guolong | Yan, Jing | Ning, Gangmin

Article Type: Research Article

Abstract: Mobile health (mHealth) technology has been proposed to alleviate the lack of sufficient medical resources for personal healthcare. However, usage difficulties and compliance issues relating to this technology restrict the effect of mHealth system-supported self-management. In this study, an mHealth framework is introduced to overcome these drawbacks and improve the outcome of self-management. We implemented a set of ease of use principles in the mHealth design and employed the quantitative Fogg Behavior Model to enhance users’ execution ability. The framework was realized in a prototype design for the mHealth system, which consists of medical apparatuses, mobile applications and a health …management server. The system is able to monitor the physiological status in an unconstrained manner with simplified operations, while supervising the healthcare plan. The results suggest that the present framework design is accessible for ordinary users and effective in improving users’ execution ability in self-management. Show more

Keywords: Self-management, mobile health, execution ability, ease of use, persuasive technology

DOI: 10.3233/BME-151473

Citation: Bio-Medical Materials and Engineering, vol. 26, no. s1, pp. S1731-S1740, 2015

Authors: Lim, Hyung-Gyu | Kim, Jong Hoon | Shin, Dong Ho | Woo, Seong Tak | Seong, Ki Woong | Lee, Jyung Hyun | Kim, Myoung Nam | Wei, Qun | Cho, Jin-Ho

Article Type: Research Article

Abstract: Many types of fully implantable hearing aids have been developed. Most of these devices are implanted behind the ear. To maintain the implanted device for a long period of time, a rechargeable battery and wireless power transmission are used. Because inductive coupling is the most renowned method for wireless power transmission, many types of fully implantable hearing aids are transcutaneously powered using inductively coupled coils. Some patients with an implantable hearing aid require a method for conveniently charging their hearing aid while they are resting or sleeping. To address this need, a wireless charging pillow has been developed that employs …a circular array coil as one of its primary parts. In this device, all primary coils are simultaneously driven to maintain an effective charging area regardless of head motion. In this case, however, there may be a magnetic weak zone that cannot be charged at the specific secondary coil’s location on the array coil. In this study, assuming that a maximum charging distance is 4 cm, a circular array coil—serving as a primary part of the charging pillow—was designed using finite element analysis. Based on experimental results, the proposed device can charge an implantable hearing aid without a magnetic weak zone within 4 cm of the perpendicular distance between the primary and secondary coils. Show more

Keywords: Wireless charging pillow, fully implantable hearing aid, inductive coupling, circular array coil, magnetic weak zone

DOI: 10.3233/BME-151474

Citation: Bio-Medical Materials and Engineering, vol. 26, no. s1, pp. S1741-S1747, 2015

Authors: Nguyen, Tan Loc | Won, Yonggwan

Article Type: Research Article

Abstract: Snoring detection is important for diagnosing obstructive sleep apnea syndrome (OSAS) and other respiratory sleep disorders. In general, audio signal processing such as snoring sound analysis uses the frequency characteristics of the signal. Recently, a correlational filter Multilayer Perceptron neural network (f-MLP) has been proposed, which has the first hidden layer of correlational filter operations in frequency domain. It demonstrated a superior classification performance for the pattern sets; of these, frequency information is the dominant feature for classification. The first hidden layer is implemented with the correlational filter operation; its output is the power spectrum of the filter output, while …the other layers are the same as the ordinary multilayer Perceptron (o-MLP). By using the back-propagation learning algorithm for the correlational filter layer, f-MLP was able to self-adapt the filter coefficients to produce its output with more discrimination power for classification in the higher layer. In this research, this f-MLP was applied for sleep snoring signal detection. As a result, the f-MLP achieved an average detection rate of 96% for the test patterns, compared to the conventional multilayer neural network that demonstrates an 82% average detection rate. Show more

Keywords: Sleep snoring, Fourier transform, correlational filter, classification, multilayer perceptron neural network

DOI: 10.3233/BME-151475

Citation: Bio-Medical Materials and Engineering, vol. 26, no. s1, pp. S1749-S1755, 2015

Authors: Zhou, Xi Y. | Tian, Xue W. | Lim, Joon S.

Article Type: Research Article

Abstract: In the data mining field, classification is a very crucial technology, and the Bayesian classifier has been one of the hotspots in classification research area. However, assumptions of Naive Bayesian and Tree Augmented Naive Bayesian (TAN) are unfair to attribute relations. Therefore, this paper proposes a new algorithm named Fuzzy Naive Bayesian (FNB) using neural network with weighted membership function (NEWFM) to extract regulated relations and weights. Then, we can use regulated relations and weights to construct a regulated network. Finally, we will classify the heart and Haberman datasets by the FNB network to compare with experiments of Naive Bayesian …and TAN. The experiment results show that the FNB has a higher classification rate than Naive Bayesian and TAN. Show more

Keywords: Naive Bayesian, Tree Augmented Naive Bayesian, Fuzzy Naive Bayesian, fuzzy neural network, weights

DOI: 10.3233/BME-151476

Citation: Bio-Medical Materials and Engineering, vol. 26, no. s1, pp. S1757-S1762, 2015

Authors: Ha, Jihwan | Kim, Hyunjin | Yoon, Youngmi | Park, Sanghyun

Article Type: Research Article

Abstract: MicroRNAs (miRNA) are known to be involved in the development of various diseases. Hence various scientists in the field have been utilized computational analyses to determine the relationship between miRNA and diseases. However, the knowledge of miRNA and disease is still very limited. Therefore, we combined Environmental Factor (EF) data to a miRNA global network. Increasing research has shown that relationship between miRNAs and EFs play a significant role in classifying types of diseases. Environmental Factors consist of radiation, drugs, viruses, alcohol, cigarettes, and stress. Our global network considered all the interactions between every pair of miRNAs, which has led …to precise analyses in comparison to local networks. As a result, our approaches’ performance demonstrated its effectiveness in identifying disease-related miRNA and this is the area under the ROC curve (AUC) of 74.46%. Furthermore, comparative experiment has shown that our approach performs comparable to other existing methods with an accuracy of 94%, 90% and 96% for breast cancer, colonic cancer, and lung cancer respectively. In conclusion, these results support that our research has broadened new biological insights on identifying disease-related miRNAs. Show more

Keywords: miRNA, disease, environmental factor, network, propagation algorithm

DOI: 10.3233/BME-151477

Citation: Bio-Medical Materials and Engineering, vol. 26, no. s1, pp. S1763-S1772, 2015

Authors: Kim, Ji-Sun | Kim, A-Hee | Oh, Han-Byeol | Goh, Bong-Jun | Lee, Eun-Suk | Kim, Jun-Sik | Jung, Gu-In | Baek, Jin-Young | Jun, Jae-Hoon

Article Type: Research Article

Abstract: A spectrophotometer is the basic measuring equipment essential to most research activity fields requiring samples to be measured, such as physics, biotechnology and food engineering. This paper proposes a system that is able to detect sample concentration and color information by using LED and color sensor. Purity and wavelength information can be detected by CIE diagram, and the concentration can be estimated with purity information. This method is more economical and efficient than existing spectrophotometry, and can also be used by ordinary persons. This contribution is applicable to a number of fields because it can be used as a colorimeter …to detect the wavelength and purity of samples. Show more

Keywords: Color information, color space, light emitting diode, spectrophotometer

DOI: 10.3233/BME-151478

Citation: Bio-Medical Materials and Engineering, vol. 26, no. s1, pp. S1773-S1780, 2015

Authors: Manzoor, Umar | Shahid, Sarosh | Zafar, Bassam

Article Type: Research Article

Abstract: Multiple sequence alignment plays a key role in the computational analysis of biological data. Different programs are developed to analyze the sequence similarity. This paper highlights the algorithmic techniques of the most popular multiple sequence alignment programs. These programs are then evaluated on the basis of execution time and scalability. The overall performance of these programs is assessed to highlight their strengths and weaknesses with reference to their algorithmic techniques. In terms of overall alignment quality, T-Coffee and Mafft attain the highest average scores, whereas K-align has the minimum computation time.

Keywords: Multiple sequence alignment, clustalW, k-align, muscle, mafft, t-coffee, progressive alignment

DOI: 10.3233/BME-151479

Citation: Bio-Medical Materials and Engineering, vol. 26, no. s1, pp. S1781-S1789, 2015

Authors: Jo, Heeseung | Koh, Gunhwan

Article Type: Research Article

Abstract: Due to next-generation sequencing (NGS) technology, genome sequencing is able to process much more data at low cost. In NGS data analysis, the mapping of sequences into a reference genome takes the largest amount of time to process. Although the Burrows-Wheeler Aligner (BWA) tool is one of the most widely used open-source software tools to align read sequences, it is still limited in that it does not fully support multi-thread mechanisms during the alignment steps. In this paper, we propose a BWA-MT tool, evolved from BWA but supporting multi-thread computation, designed to fully utilize the underlying multi-core architecture of computing …resources. By using multi-thread computation, BWA-MT can significantly shorten the time needed to generate an alignment for single-end read sequences. Meanwhile, it generates an identical Sequence Alignment Map (SAM) result file as BWA. To evaluate BWA-MT, we use an evaluation system equipped with twelve cores and 32 GB memory. As a workload, we used the hg19 human genome reference sequence and various numbers of read sequences from 1M to 40M. In our evaluation, BWA-MT displays up to 3.7 times faster performance and generates an identical SAM result file to BWA. Although the increased speed might be dependent on computing resources, we confirm that BWA-MT is highly efficient and effective. Show more

Keywords: genome sequencing, next-generation sequencing (NGS), burrow-wheeler aligner (BWA) tool, multi-thread

DOI: 10.3233/BME-151480

Citation: Bio-Medical Materials and Engineering, vol. 26, no. s1, pp. S1791-S1796, 2015

Authors: Song, Dandan | Li, Ning | Liao, Lejian

Article Type: Research Article

Abstract: Due to the generation of enormous amounts of data at both lower costs as well as in shorter times, whole-exome sequencing technologies provide dramatic opportunities for identifying disease genes implicated in Mendelian disorders. Since upwards of thousands genomic variants can be sequenced in each exome, it is challenging to filter pathogenic variants in protein coding regions and reduce the number of missing true variants. Therefore, an automatic and efficient pipeline for finding disease variants in Mendelian disorders is designed by exploiting a combination of variants filtering steps to analyze the family-based exome sequencing approach. Recent studies on the Freeman-Sheldon disease …are revisited and show that the proposed method outperforms other existing candidate gene identification methods. Show more

Keywords: Mendelian disorders, disease gene identification, whole-exome sequencing

DOI: 10.3233/BME-151481

Citation: Bio-Medical Materials and Engineering, vol. 26, no. s1, pp. S1797-S1803, 2015