Searching for just a few words should be enough to get started. If you need to make more complex queries, use the tips below to guide you.
Article type: Research Article
Authors: Paul, C. Alice A.E.a | Sansom, Andrew J.a; b | Maclennan, Karyna | Darlington, Cynthia L.b | Smith, Paul F.a;
Affiliations: [a] Department of Pharmacology, School of Medical Sciences, University of Otago Medical School, Dunedin, New Zealand | [b] Department of Psychology and the Neuroscience Research Centre, University of Otago, Dunedin, New Zealand
Note: [1] Reprint address: Dr. Paul F. Smith, Dept. of Pharmacology, School of Medical Sciences, University of Otago Medical School, Dunedin, New Zealand. Tel: +64-3-479-7253; Fax: +64-3-479-9140; E-mail: paul.smith@stonebow.otago.ac.nz
Abstract: Recent studies have suggested that steroids such as dexamethasone and methylprednisolone might be useful in the treatment of vestibular disorders, irrespective of whether inflammatory processes are involved. The aim of this study was to investigate the effects of systemic administration of dexamethasone on vestibular compensation of spontaneous nystagmus (SN) in guinea pig, and the effects of dexamethasone and methylprednisolone on extracellularly recorded spontaneous activity of medial vestibular nucleus (MVN) neurons in brainstem slices in vitro. In the behavioral study, none of the 3 doses of dexamethasone (5, 10, or 40 mg/kg ip, delivered at 0, 12, 24, and 36 h following a unilateral surgical labyrinthectomy (UL)) resulted in a significant change in the frequency or compensation of SN, relative to the vehicle control group. In the in vitro study, only a minority of MVN neurons showed any response to 1μM dexamethasone (lout of 9 neurons), or 10 nM (3 out of 13), or 0.1μM methylprednisolone (3 out of 7). These results suggest, contrary to previous evidence, that dexamethasone may not accelerate compensation of SN following surgical UL and that dexamethasone and methylprednisolone may have a direct action only on a minority of MVN neurons.
Keywords: vestibular compensation, medial vestibular nucleus, vestibular disorders, steroids, methylprednisolone
DOI: 10.3233/VES-1998-8302
Journal: Journal of Vestibular Research, vol. 8, no. 3, pp. 201-207, 1998
IOS Press, Inc.
6751 Tepper Drive
Clifton, VA 20124
USA
Tel: +1 703 830 6300
Fax: +1 703 830 2300
sales@iospress.com
For editorial issues, like the status of your submitted paper or proposals, write to editorial@iospress.nl
IOS Press
Nieuwe Hemweg 6B
1013 BG Amsterdam
The Netherlands
Tel: +31 20 688 3355
Fax: +31 20 687 0091
info@iospress.nl
For editorial issues, permissions, book requests, submissions and proceedings, contact the Amsterdam office info@iospress.nl
Inspirees International (China Office)
Ciyunsi Beili 207(CapitaLand), Bld 1, 7-901
100025, Beijing
China
Free service line: 400 661 8717
Fax: +86 10 8446 7947
china@iospress.cn
For editorial issues, like the status of your submitted paper or proposals, write to editorial@iospress.nl
如果您在出版方面需要帮助或有任何建, 件至: editorial@iospress.nl