Journal of Vestibular Research - Volume 31, issue 6

Authors: Yadav, Harsha | Irugu, DVK | Ramakrishanan, Lakshmy | Singh, Archana | Abraham, Ransi | Sikka, Kapil | Thakar, Alok | Verma, Hitesh

Article Type: Research Article

Abstract: BACKGROUND: Serum otolin-1 is an inner ear protein exclusively expressed in otoconia and cells of vestibule and cochlea. Serum otolin-1 is found to be quantifiable in patients with BPPV. Low Vitamin-D is associated with pathogenesis of BPPV. Since otoconia degeneration contributes to BPPV, lack of Vitamin-D may impact otoconia structure and integrity. OBJECTIVE: We aimed at studying the s.otolin-1 as biomarker and significance of vit-D in BPPV. MATERIAL AND METHOD: 23 patients in test and control groups respectively were chosen within the age of 20 to 65 years. All the patients were diagnosed using Dix Hallpike …menouver and head roll test, patients were treated with appropriate Canal Reposition Menouver (CRM). RESULTS: Serum Otolin-1 levels among the test ranged from 366 to 882 pg/mL with mean of 585.17 pg/mL whereas in control group ranged from 223 to 462 pg/mL with mean of 335.26 pg/mL. Mean Vitamin-D levels among the test group was 22.67 ng/mL (Range = 6.3–68.4) and that of control 15.43 pg/mL (Range = 5.4–27.7) respectively. The relationship between the serum Otolin-1 and Vitamin-D was not statistically significant. CONCLUSION: Otolin-1 levels is increased in BPPV patients and is sensitive in BPPV, specificity needs to be validated. Role of vitamin-D with respect to inner ear proteins needs further investigation. Show more

Keywords: Otolin-1, vitamin D, inner ear, Dix hallpike, canalith reposition procedure, semicircular canal

DOI: 10.3233/VES-201601

Citation: Journal of Vestibular Research, vol. 31, no. 6, pp. 433-440, 2021

Authors: Xu, Yinfang | Yang, Liping | Zhao, Xing | Zhang, Yan | Jones, Timothy A. | Jones, Sherri M. | Lundberg, Yunxia Wang

Article Type: Research Article

Abstract: BACKGROUND: Otoconia-related vertigo and balance deficits are common in humans, but the molecular etiology is unknown at present. OBJECTIVE: In order to study mechanisms of otoconia formation and maintenance, we have investigated whether otoconin-90 (Oc90), the predominant otoconial constituent protein, and the NADPH oxidase Nox3, an essential regulatory protein for otoconia formation, are functionally interlinked. METHODS: We performed balance behavioral, electrophysiological, morphological and molecular cellular analyses. RESULTS: Double heterozygous mutant mice for Oc90 and Nox3 show severe imbalance, albeit less profound than double null mutants. In contrast, single heterozygous mutant mice have …normal balance. Double heterozygous mice have otoconia defects and double null mice have no otoconia. In addition, some hair bundles in the latter mice go through accelerated degeneration. In vitro calcification analysis in cells stably expressing these proteins singly and doubly shows much more intense calcification in the double transfectants. CONCLUSIONS: Oc90 and Nox3 augment each other’s function, which is not only critical for otoconia formation but also for hair bundle maintenance. Show more

Keywords: Oc90, Nox3, calcification, hair bundle, balance

DOI: 10.3233/VES-201591

Citation: Journal of Vestibular Research, vol. 31, no. 6, pp. 441-449, 2021

Authors: Tribukait, Arne | Eiken, Ola

Article Type: Research Article

Abstract: BACKGROUND: Recent theories suggest that perception of complex self-motion is governed by familiarity of the motion pattern as a whole in 3D. OBJECTIVE: To explore how familiarity determines the perceived angular displacement with respect to the Earth during a simulated coordinated turn in a gondola centrifuge. METHOD: The centrifuge was accelerated to 2G (gondola displacement 60°) within 12.5 s. Using visual indicators in darkness, responses to the gondola displacement were recorded with subjects (n  = 10) in two positions: sitting-upright, facing-forward versus lying-supine, feet-forwards. Each subject underwent 2×2 6-minute runs. RESULT: When upright, subjects indicated a …tilt of initially 18.8±11.3°, declining with T  = 66±37 s. In the supine position (subject’s yaw plane coinciding with the plane of gondola displacement) the indicated displacement was negligible (–0.3±4.8°). CONCLUSION: Since the canal system is most responsive to stimuli in yaw, these findings are difficult to explain by bottom-up models. Rather, the motion pattern during acceleration would be recognized as a familiar or meaningful whole (entering a co-ordinated turn) only when the subject is upright. Presumably, the degree of familiarity is reflected in the subject’s ability to discern and estimate a single stimulus component. Findings are discussed in connection with human factors in aviation and the principles of Gestalt psychology. Show more

Keywords: Vestibular system, spatial disorientation, self-motion perception, Gestalt psychology, pattern recognition, subjective horizontal, subjective vertical, top-down processing

DOI: 10.3233/VES-201527

Citation: Journal of Vestibular Research, vol. 31, no. 6, pp. 451-467, 2021

Authors: Anson, E. | Ehrenburg, M.R. | Simonsick, E.M. | Agrawal, Y.

Article Type: Research Article

Abstract: BACKGROUND: Spatial orientation is a complex process involving vestibular sensory input and possibly cognitive ability. Previous research demonstrated that rotational spatial orientation was worse for individuals with profound bilateral vestibular dysfunction. OBJECTIVE: Determine whether rotational and linear vestibular function were independently associated with large amplitude rotational spatial orientation perception in healthy aging. METHODS: Tests of rotational spatial orientation accuracy and vestibular function [vestibulo-ocular reflex (VOR), ocular and cervical vestibular evoked myogenic potentials (VEMP)] were administered to 272 healthy community-dwelling adults participating in the Baltimore Longitudinal Study of Aging. Using a mixed model multiple linear regression we …regressed spatial orientation errors on lateral semicircular canal function, utricular function (ocular VEMP), and saccular function (cervical VEMP) in a single model controlling for rotation size, age, and sex. RESULTS: After adjusting for age, and sex, individuals with bilaterally low VOR gain (β = 20.9, p  = 0.014) and those with bilaterally absent utricular function (β = 9.32, p  = 0.017) made significantly larger spatial orientation errors relative to individuals with normal vestibular function. CONCLUSIONS: The current results demonstrate for the first time that either bilateral lateral semicircular canal dysfunction or bilateral utricular dysfunction are associated with worse rotational spatial orientation. We also demonstrated in a healthy aging cohort that increased age also contributes to spatial orientation ability. Show more

Keywords: Vestibular function, visuospatial ability, aging, spatial orientation

DOI: 10.3233/VES-201582

Citation: Journal of Vestibular Research, vol. 31, no. 6, pp. 469-478, 2021

Authors: Yang, Alexander Hui Xiang | Khwaounjoo, Prashanna | Cakmak, Yusuf Ozgur

Article Type: Research Article

Abstract: BACKGROUND: Neural circuits allow whole-body yaw rotation to modulate vagal parasympathetic activity, which alters beat-to-beat variation in heart rate. The overall output of spinning direction, as well as vestibular-visual interactions on vagal activity still needs to be investigated. OBJECTIVE: This study investigated direction-dependent effects of visual and natural vestibular stimulation on two autonomic responses: heart rate variability (HRV) and pupil diameter. METHODS: Healthy human male subjects (n  = 27) underwent constant whole-body yaw rotation with eyes open and closed in the clockwise (CW) and anticlockwise (ACW) directions, at 90°/s for two minutes. Subjects also viewed the same …spinning environments on video in a VR headset. RESULTS: CW spinning significantly decreased parasympathetic vagal activity in all conditions (CW open p  = 0.0048, CW closed p  = 0.0151, CW VR p  = 0.0019,), but not ACW spinning (ACW open p  = 0.2068, ACW closed p  = 0.7755, ACW VR p  = 0.1775,) as indicated by an HRV metric, the root mean square of successive RR interval differences (RMSSD). There were no direction-dependent effects of constant spinning on sympathetic activity inferred through the HRV metrics, stress index (SI), sympathetic nervous system index (SNS index) and pupil diameter. Neuroplasticity in the CW eyes closed and CW VR conditions post stimulation was observed. CONCLUSIONS: Only one direction of yaw spinning, and visual flow caused vagal nerve neuromodulation and neuroplasticity, resulting in an inhibition of parasympathetic activity on the heart, to the same extent in either vestibular or visual stimulation. These results indicate that visual flow in VR can be used as a non-electrical method for vagus nerve inhibition without the need for body motion in the treatment of disorders with vagal overactivity. The findings are also important for VR and spinning chair based autonomic nervous system modulation protocols, and the effects of motion integrated VR. Show more

Keywords: Vestibular system, heart rate variability, vagal activity, stress index, RMSSD, virtual reality, visual flow, direction, laterality, rotation, barany chair, spinning chair, pupil diameter, pupil size, cardiac responses, autonomic modulation, neuromodulation, vestibular stimulation

DOI: 10.3233/VES-201574

Citation: Journal of Vestibular Research, vol. 31, no. 6, pp. 479-494, 2021

Authors: Thompson-Harvey, Adam | Dutcher, Charlotte E. | Monroe, Heather A. | Sinks, Belinda C. | Goebel, Joel A.

Article Type: Research Article

Abstract: BACKGROUND: The Gaze Stabilization Test (GST) identifies vestibulo-ocular reflex (VOR) dysfunction using a decline in target recognition with increasing head velocity, but there is no consensus on target (optotype) size above static visual acuity. OBJECTIVE: To determine the optimal optotype size above static visual acuity to be used during the GST in subjects with unilateral vestibular dysfunction and healthy individuals. METHODS: Eight subjects with unilateral vestibular dysfunction (UVD) and 19 age-matched, healthy control subjects were studied with the standard GST protocol using two optotype sizes, 0.2 and 0.3 logMAR above static visual acuity (Δ logMAR). Maximal …head velocity achieved while maintaining fixation on both optotypes was measured. Sensitivity, specificity and receiver-operator characteristic area under the curve (ROC AUC) analyses were performed to determine the optimal head velocity cut off point for each optotype, based on ability to identify the lesioned side of the UVD group from the control group. RESULTS: There was a significant difference in maximal head velocity between the UVD group and control group using 0.2 Δ logMAR (p  = 0.032) but not 0.3 Δ logMAR (p  = 0.061). While both targets produced similar specificities (90%) for distinguishing normal from subjects with UVD, 0.2 Δ logMAR targets yielded higher sensitivity (75%) than 0.3 logMAR (63%) and accuracy (86% vs 80%, respectively) in detecting the lesioned side in subjects with UVD versus controls with maximal head velocities≤105 deg/s (p  = 0.017). Furthermore, positive likelihood ratios were nearly twice as high when using 0.2 Δ logMAR targets (+ LR 10) compared to 0.3 Δ logMAR (+ LR 6.3). CONCLUSION: The 0.2 Δ logMAR optotype demonstrated significantly superior identification of subjects with UVD, better sensitivity and positive likelihood ratios than 0.3 Δ logMAR for detection of VOR dysfunction. Using a target size 0.2logMAR above static visual acuity (Δ logMAR) during GST may yield better detection of VOR dysfunction to serve as a baseline for gaze stabilization rehabilitation therapy. Show more

Keywords: Gaze stabilization test, vestibular testing, vestibulo-ocular reflex (VOR), visual acuity, vestibular rehabilitation

DOI: 10.3233/VES-201602

Citation: Journal of Vestibular Research, vol. 31, no. 6, pp. 495-504, 2021

Authors: Lubetzky, Anat V. | Aharoni, Moshe M.H. | Arie, Liraz | Krasovsky, Tal

Article Type: Research Article

Abstract: BACKGROUND: People with PPPD report imbalance, increase in symptoms and impaired function within complex visual environments, but understanding of the mechanism for these behaviors is still lacking. OBJECTIVE: To investigate postural control in PPPD we compared changes in center of pressure (COP) and head kinematics of people with PPPD (N = 22) and healthy controls (N = 20) in response to different combinations of visual and cognitive perturbations during a challenging balance task. METHODS: Participants stood in a tandem position. Static or moving stars (0.2 Hz, 5 mm or 32 mm amplitude, anterior-posterior direction) were displayed through a head-mounted display (HTC Vive). On …half the trials, participants performed a serial-3 subtraction task. We measured medio-lateral and anterior-posterior path and acceleration of COP and head. RESULTS: Controls significantly increased all COP and head parameters with the cognitive task whereas PPPD increased only COP ML path and acceleration. Only controls significantly increased head anterior-posterior & medio-lateral acceleration with moving visual load. Cognitive task performance was similar between groups. CONCLUSIONS: We observed altered postural strategies in people with PPPD, in the form of reduced movement with challenge, particularly around the head segment. The potential of this simple and portable head-mounted display setup for differential diagnosis of vestibular disorders should be further explored. Show more

Keywords: PPPD, balance, sensory integration, dual task, head mounted display, virtual reality

DOI: 10.3233/VES-201552

Citation: Journal of Vestibular Research, vol. 31, no. 6, pp. 505-517, 2021

Authors: Campbell, Kody R. | Parrington, Lucy | Peterka, Robert J. | Martini, Douglas N. | Hullar, Timothy E. | Horak, Fay B. | Chesnutt, James C. | Fino, Peter C. | King, Laurie A.

Article Type: Research Article

Abstract: BACKGROUND: Little is known on the peripheral and central sensory contributions to persistent dizziness and imbalance following mild traumatic brain injury (mTBI). OBJECTIVE: To identify peripheral vestibular, central integrative, and oculomotor causes for chronic symptoms following mTBI. METHODS: Individuals with chronic mTBI symptoms and healthy controls (HC) completed a battery of oculomotor, peripheral vestibular and instrumented posturography evaluations and rated subjective symptoms on validated questionnaires. We defined abnormal oculomotor, peripheral vestibular, and central sensory integration for balance measures among mTBI participants as falling outside a 10-percentile cutoff determined from HC data. A X -squared test associated …the proportion of normal and abnormal responses in each group. Partial Spearman’s rank correlations evaluated the relationships between chronic symptoms and measures of oculomotor, peripheral vestibular, and central function for balance control. RESULTS: The mTBI group (n  = 58) had more abnormal measures of central sensory integration for balance than the HC (n  = 61) group (mTBI: 41% –61%; HC: 10%, p’s < 0.001), but no differences on oculomotor and peripheral vestibular function (p  > 0.113). Symptom severities were negatively correlated with central sensory integration for balance scores (p ’s < 0.048). CONCLUSIONS: Ongoing balance complaints in people with chronic mTBI are explained more by central sensory integration dysfunction rather than peripheral vestibular or oculomotor dysfunction. Show more

Keywords: Peripheral vestibular function, oculomotor function, central sensory integration, postural control, mild traumatic brain injury

DOI: 10.3233/VES-201590

Citation: Journal of Vestibular Research, vol. 31, no. 6, pp. 519-530, 2021

Authors: Casani, Augusto Pietro | Canelli, Rachele | Lazzerini, Francesco | Navari, Elena

Article Type: Research Article

Abstract: OBJECTIVES: This cross-sectional study aims to describe the features of the suppression head impulse paradigm (SHIMP) in acute unilateral vestibulopathy (AUV) and to define its role in predicting the recovery of patients. METHODS: Thirty patients diagnosed with AUV were retrospectively analyzed. The dizziness handicap inventory score and video head impulse test parameters performed 4–8 weeks from the AUV onset constituted the main outcome measures. Patients with a worse recovery (Group 1) and patients who recovered spontaneously (Group 2) were compared. RESULTS: The SHIMP vestibulo-ocular reflex (VOR) gain was statistically significantly lower than the conventional head impulse …paradigm (HIMP) VOR gain (P  < 0.001). The SHIMP VOR gain was negatively correlated with the DHI (P  < 0.001) and was positively correlated with the HIMP VOR gain (P  < 0.001) and the SHIMP overt saccades (%) (P  < 0.001). Patients with a worse recovery exhibited the following: higher DHI (P  < 0.001), lower SHIMP and HIMP VOR gain (P  < 0.001 and P  = 0.007, respectively), and lower SHIMP and greater HIMP overt saccade prevalence values (P  = 0.007 and P  = 0.032, respectively). CONCLUSIONS: The SHIMP and HIMP help in improving our approach to AUV. SHIMP appears to better identify the extent of the vestibular damage in patient suffering from AUV than HIMP and could provide interesting information about the course of the disease. Particularly, the analysis of SHIMP VOR gain and overt saccade prevalence would provide useful information about the recovery of patients. Show more

Keywords: Video head impulse test, vestibular neuritis, acute unilateral vestibulopathy, vestibular rehabilitation, vertigo, vestibular compensation, SHIMP, HIMP

DOI: 10.3233/VES-210038

Citation: Journal of Vestibular Research, vol. 31, no. 6, pp. 531-540, 2021

Authors: Lotfi, Yones | Farahani, Akram | Azimiyan, Mojtaba | Moossavi, Abdollah | Bakhshi, Enayatollah

Article Type: Research Article

Abstract: BACKGROUND: Dizziness and imbalance are common symptoms in patients with multiple sclerosis (PwMS), and rehabilitation interventions varying greatly in effectiveness. OBJECTIVE: To compare the effectiveness of vestibular rehabilitation therapy (VRT) and noisy galvanic vestibular stimulation (nGVS) on dizziness and balance in PwMS. METHODS: This was a single-blind, randomized controlled trial. Twenty-four PwMS were randomly divided into groups of VRT, nGVS, and Control. The VRT and the nGVS groups underwent the intervention program. The patients were assessed with the composite score in anteroposterior and lateral directions (CS AP and LAT) obtained by sensory organization test (SOT), Dizziness …Handicap Inventory (DHI), and Activities-Specific Balance Confidence Scale (ABC). RESULTS: The VRT group showed greater improvements in CS AP and LAT, DHI total score, and ABC total score compared with the nGVS group and the control group. No significant difference was found between the nGVS group and the control group. These results were approximately stable at the 4-week follow-up. CONCLUSIONS: These findings provided evidence for effectiveness of the VRT in improvement of dizziness and balance in PwMS. These improvements were not associated with the nGVS. Further studies are needed to assess the effectiveness of the nGVS on dizziness and balance in PwMS. Show more

Keywords: Multiple sclerosis, vestibular rehabilitation, noisy galvanic vestibular stimulation, balance, dizziness

DOI: 10.3233/VES-201609

Citation: Journal of Vestibular Research, vol. 31, no. 6, pp. 541-551, 2021