Affiliations: [a] Department of Otolaryngology, University of Pittsburgh, PA, USA | [b] Bioengineering, University of Pittsburgh, PA, USA | [c] Physical Therapy, University of Pittsburgh, PA, USA | [d] Neurology, Neurological Institute, Taipei Veterans General Hospital, and National Yang-Ming University School of Medicine, Taipei, Taiwan
Correspondence:
[*]
Corresponding author: Joseph M. Furman, Eye & Ear Institute Building, Suite 500, 200 Lothrop Street, Pittsburgh, PA 15213, USA. Tel.: +1 412 647 2117; Fax: +1 412 647 2080; E-mail: furman@pitt.edu
Abstract: The chronic effects of unilateral peripheral vestibular loss (UPVL) are influenced by vestibular compensation. This study documents the balance-related symptoms and quantitative vestibular laboratory testing of 20 patients with surgically confirmed UPVL. Included are measures of the semicircular canal-ocular reflex, the otolith-ocular reflex, and both static and dynamic semicircular canal-otolith-interaction. This study differs from previous studies of patients with UPVL in that a large number of patients with surgically confirmed lesions were tested with three types of off-vertical axis rotation, several of the patients had anatomically preserved superior vestibular nerves, and self-perceived level of disability related to dizziness and imbalance were available. Results confirmed previously reported changes in the vestibulo-ocular reflex of patients with UPVL. Also, there was no apparent effect of anatomically preserving the superior vestibular nerve during surgical resection of vestibular schwannomas based on either subjective or objective measures of vestibular dysfunction. Further, there were no apparent correlations between subjective measures of dizziness and imbalance and objective measures of vestibulo-ocular function. These results have clinical implications for the management of patients with unilateral vestibular loss and provide insights into the process of vestibular compensation especially with respect to the otolith-ocular reflex.
