Restorative Neurology and Neuroscience - Volume 38, issue 6

Authors: Kim, Jinuk | Kim, Heegoo | Lee, Jungsoo | Lee, Hwang-Jae | Na, Yoonju | Chang, Won Hyuk | Kim, Yun-Hee

Article Type: Research Article

Abstract: Background: Low-frequency rTMS can induce upregulation of excitability in the contralateral hemisphere by interhemispheric interaction. Objective: The aim of this study was to compare the effects of interhemispheric modulation on hemodynamic changes after applying low-frequency rTMS over the anatomical hand knob (HK) and the hand motor hotspot (hMHS) in the dominant motor cortex. Methods: Ten healthy right-handed participants without a history of neurological or psychiatric symptoms (five males; 29.8±2.8 years) participated in this single-blind, randomized, cross-over study. rTMS was applied under three conditions over the dominant (left) hemisphere for 20 minutes: 1) 1 Hz rTMS stimulation on …the HK (HK-rTMS), 2) 1 Hz rTMS stimulation on the hMHS (hMHS-rTMS), and 3) sham stimulation (Sham-rTMS). For all participants, functional near-infrared spectroscopy (fNIRS) was applied for measurement of cerebral oxyhemoglobin (oxyHb) and deoxyhemoglobin (deoxyHb) concentration over the non-dominant (right) hemisphere during a serial reaction time task (SRTT) with the non-dominant (left) hand before and after each condition. Results: The average coordinates of the hMHS (x = – 39.60 mm, y = – 17.11 mm, z = 66.40 mm) were anterior and lateral to the HK (x = – 36.72 mm, y = – 28.87 mm, z = 56.41 mm). In fNIRS time-series analysis, the integral value of oxyHb was significantly increased over the motor cortical region of the non-dominant hemisphere after the hMHS-rTMS compared with Sham-rTMS. The HK-rTMS also showed slight increment of oxyHb concentration but without statistical significance. The SPM group analysis showed greater magnitude of the activity in hMHS-rTMS than that of HK-rTMS after stimulation (p  < 0.05). Conclusions: These results demonstrated an interhemispheric modulation effect of hemodynamic changes by 1 Hz rTMS. The hMHS produced a more robust modulation effect of 1 Hz rTMS on the contralateral hemisphere than did the HK. Therefore, the rTMS can be considered a better stimulation target than the HK. Show more

Keywords: Near-infrared spectroscopy, transcranial magnetic stimulation, Interhemispheric modulation, hand motor hot spot, hand knob

DOI: 10.3233/RNN-201032

Citation: Restorative Neurology and Neuroscience, vol. 38, no. 6, pp. 407-417, 2020

Authors: Ahn, Si-nae

Article Type: Research Article

Abstract: Background: Continued long-term rehabilitation programs with acquired brain injury are important for their participation in meaningful daily activities. Objective: This paper investigated the participation-based interventions on outcomes in patients with acquired brain injury. Methods: A systematic review and meta-analysis search for randomized control trials published between 1998 and 2019 using PubMed, CINAHL, and MEDLINE was performed. Nine studies were selected and analyzed for systematic review. Five studies analyzed the effectiveness of participation-based intervention using meta-analysis and assessed the level of evidence of qualitative studies. Results: A total of 843 publications were searched. Nine studies …met the inclusion criteria and were of high quality. The effective score for improving participation following participation-based interventions in persons with acquired brain injury was 0.32 and significant in this study (p  < 0.05). Conclusions: The findings of this systematic review and meta-analysis suggest that, in persons with acquired brain injury, participation-based interventions are essential for community living. Show more

Keywords: Community participation, intervention, participation

DOI: 10.3233/RNN-201074

Citation: Restorative Neurology and Neuroscience, vol. 38, no. 6, pp. 419-429, 2020

Authors: Elnaggar, Ragab K. | Alqahtani, Bader A. | Elbanna, Mohammed F.

Article Type: Research Article

Abstract: Background: The integration of therapeutic approaches is increasingly recommended for children with cerebral palsy, to enhance outcomes. Nevertheless, clinicians still opt for separate or combined therapies based on little credible knowledge. Objective: This study endeavored to evaluate the effect of botulinum neurotoxin-A (BoNT-A) injection and reciprocal neuromuscular electrical stimulation (rNMES) and their combination on the upper extremity function in children with spastic hemiplegia. Methods: Sixty-four children with spastic hemiplegia (aged 6– 10 years) were randomly assigned to four treatment-based groups [group I (BoNT-A), group II (rNMES), group III (combined BoNT-A and rNMES), and group IV (Control)]. …All children received a physical rehabilitation program, thrice/week over three months. Unilateral upper-limb function, bimanual hand function, and real-time arm-hand function were assessed using Melbourne Assessment (MA), Assisting Hand Assessment (AHA), and Pediatric Motor Activity Log (PMAL) scales respectively pre-treatment, post-treatment, and at 6 months follow-up. Results: Post-treatment, group III achieved greater improvement in MA, AHA, and PMAL compared to other groups (all P  < 0.05), and the difference remained in favor of group III at the follow-up (all P  < 0.05). Conclusions: This study suggests that BoNT-A and rNMES combined are more effective than either of them alone to enhance upper-extremity function in children with spastic hemiplegia. Show more

Keywords: Cerebral palsy, muscle co-activation, electrical stimulation, botulinum-A toxin, upper extremity function

DOI: 10.3233/RNN-201088

Citation: Restorative Neurology and Neuroscience, vol. 38, no. 6, pp. 431-441, 2020

Authors: Lesch, Hendrik | Schoenfeld, Mircea Ariel | Merkel, Christian

Article Type: Research Article

Abstract: Background: A number of theoretical accounts have been put forward to explain the ability to simultaneously track multiple visually indistinguishable objects over a period of time. Serial processing models of visual tracking focus on the maintenance of the spatial locations of every single item over time. A more recent mechanism describes multiple object tracking as the ability to maintain a higher order representation of an abstract spatial configuration built by the illusory connection of the tracked items through their transition. Objective: The current study investigates the correspondence between these serial and parallel tracking accounts and the right hemispheric …specialization for the space-based vs. left hemispheric for object-based attentional processing. Methods: Electrophysiological brain responses were recorded in two groups of patients with right- and left hemispheric lesions while performing in a multiple object tracking task. Results: The results suggest a failure to distinguish single item information for the right hemispheric patients accompanied by the absence of a known electrophysiological marker associated with single item tracking. Importantly, left hemispheric patients showed a graded behavioral and electrophysiological response to probe stimuli as a function of the congruence of the probe with the relevant target stimuli. Conclusions: The current data suggest that the differential contribution of serial and parallel tracking mechanisms during object tracking can partly be explained by the different functional contributions of the right and left brain hemispheres. Show more

DOI: 10.3233/RNN-201048

Citation: Restorative Neurology and Neuroscience, vol. 38, no. 6, pp. 443-453, 2020

Authors: Okawada, Megumi | Kaneko, Fuminari | Shindo, Keiichiro | Yoneta, Masaki | Sakai, Katsuya | Okuyama, Kohei | Akaboshi, Kazuto | Liu, Meigen

Article Type: Research Article

Abstract: Background: Repetition of motor imagery improves the motor function of patients with stroke. However, patients who develop severe upper-limb paralysis after chronic stroke often have an impaired ability to induce motor imagery. We have developed a method to passively induce kinesthetic perception using visual stimulation (kinesthetic illusion induced by visual stimulation [KINVIS]). Objective: This pilot study further investigated the effectiveness of KINVIS in improving the induction of kinesthetic motor imagery in patients with severe upper-limb paralysis after stroke. Methods: Twenty participants (11 with right hemiplegia and 9 with left hemiplegia; mean time from onset [±standard deviation], …67.0±57.2 months) with severe upper-limb paralysis who could not extend their paretic fingers were included in this study. The ability to induce motor imagery was evaluated using the event-related desynchronization (ERD) recorded during motor imagery before and after the application of KINVIS for 20 min. The alpha- and beta-band ERDs around the premotor, primary sensorimotor, and posterior parietal cortices of the affected and unaffected hemispheres were evaluated during kinesthetic motor imagery of finger extension and before and after the intervention. Results: Beta-band ERD recorded from the affected hemisphere around the sensorimotor area showed a significant increase after the intervention, while the other ERDs remained unchanged. Conclusions: In patients with chronic stroke who were unable to extend their paretic fingers for a prolonged period of time, the application of KINVIS, which evokes kinesthetic perception, improved their ability to induce motor imagery. Our findings suggest that although KINVIS is a passive intervention, its short-term application can induce changes related to the motor output system. Show more

Keywords: Motor imagery, event-related desynchronization, electroencephalography, stroke, kinesthetic illusion, virtual reality

DOI: 10.3233/RNN-201030

Citation: Restorative Neurology and Neuroscience, vol. 38, no. 6, pp. 455-465, 2020

Authors: Brunelli, Stefano | Gentileschi, Noemi | Iosa, Marco | Fusco, Francesca Romana | Grossi, Valerio | Duri, Silvia | Foti, Calogero | Traballesi, Marco

Article Type: Research Article

Abstract: Background: Along with conventional therapy, novel tools are being developed in balance training for the rehabilitation of persons with stroke sequelae. The efficacy of Computerized Balance Training thus far been the object of studies only in persons with chronic stroke. Objective: To investigate the effects of an early Computerized Balance Training on balance, walking endurance and independence in activities of daily living, in persons with mild hemiparesis in subacute phase. Methods: Thirty-two persons with a recent hemiparesis (within 4 weeks from stroke onset), able to maintain a standing position for at least 30 seconds, were randomly …assigned to an experimental or control group. The control group (CG) were administered conventional physiotherapy of 40 minutes twice a day, 5 times a week for 4 weeks, while the experimental group (EG) underwent conventional physiotherapy 40 minutes once a day and Computerized Balance Training once a day, 5 times a week for 4 weeks. Outcomes were evaluated by means of Berg Balance Scale (BBS), Tinetti Balance Scale (TBS), Two Minutes Walk Test (2MWT), Barthel Index (BI) and stabilometric tests. Results: Twelve participants for each group completed the training. Each group experienced 8 dropouts. The mean age (years) was 58.1±20.4 for EG and 59.7±14,7 for CG; the days from stroke were respectively 27.9±15.5 and 20±11.7. The difference between the two groups was statistically significant in experimental group for BBS (p  = 0.003), for TBS (p  = 0.028), for Sensory Integration and Balance tests performed with closed eyes on steady (p  = 0.009) or instable surface (p  = 0.023). and for 2MWT (p  = 0.008). Conclusions: Computerized Balance Training is an effective therapeutic tool for balance and gait endurance improvement in persons with stroke in subacute phase. Show more

Keywords: Stroke, balance, rehabilitation, patient-relevant outcome, visual feedback, exercise therapy

DOI: 10.3233/RNN-201055

Citation: Restorative Neurology and Neuroscience, vol. 38, no. 6, pp. 467-475, 2020