Restorative Neurology and Neuroscience - Volume 39, issue 2

Authors: Rink, Svenja | Manthou, Maria Eleni | Arnold, Julia | Grigo, Merle | Dicken, Paulina | Abdulla, Diana Saad Yousif | Bendella, Habib | Nohroudi, Klaus | Angelov, Doychin N.

Article Type: Research Article

Abstract: Background: Physical therapy with whole body vibration (WBV) following compressive spinal cord injury (SCI) in rats restores density of perisomatic synapses, improves body weight support and leads to a better bladder function. The purpose of the study was to determine whether the combined treatment with WBV plus erythropoietin (EPO) would further improve motor, sensory and vegetative functions after SCI in rats. Methods: Severe compressive SCI at low thoracic level was followed by a single i.p. injection of 2,5μ g (250 IU) human recombinant EPO. Physical therapy with WBV started on 14th day after injury and continued over …a 12-week post injury period. Locomotor recovery, sensitivity tests and urinary bladder scores were analysed at 1, 3, 6, 9, and 12 weeks after SCI. The closing morphological measurements included lesion volume and numbers of axons in the preserved perilesional neural tissue bridges (PNTB). Results: Assessment of motor performance sensitivity and bladder function revealed no significant effects of EPO when compared to the control treatments. EPO treatment neither reduced the lesion volume, nor increased the number of axons in PNTB. Conclusions: The combination of WBV + EPO exerts no positive effects on hind limbs motor performance and bladder function after compressive SCI in rats. Show more

Keywords: Spinal cord injury, whole-body vibration, erythropoietin, locomotor performance, sensitivity, bladder function, lesion volume, number of spared axons

DOI: 10.3233/RNN-201120

Citation: Restorative Neurology and Neuroscience, vol. 39, no. 2, pp. 85-100, 2021

Authors: Osumi, Michihiro | Shimizu, Daisuke | Nishi, Yuki | Morioka, Shu

Article Type: Research Article

Abstract: Background: Patients with brachial plexus avulsion (BPA) usually experience phantom sensations and phantom limb pain (PLP) in the deafferented limb. It has been suggested that evoking the sensation of touch in the deafferented limb by stimulating referred sensation areas (RSAs) on the cheek or shoulder might alleviate PLP. However, feasible rehabilitation techniques using this approach have not been reported. Objective: The present study sought to examine the analgesic effects of simple electrical stimulation of RSAs in BPA patients with PLP. Methods: Study 1: Electrical stimulation of RSAs for 60 minutes was conducted for six BPA patients …suffering from PLP to examine short-term analgesic effects. Study 2: A single case design experiment was conducted with two BPA patients to investigate whether electrical stimulation of RSAs was more effective for alleviating PLP than control electrical stimulation (electrical stimulation of sites on side opposite to the RSAs), and to elucidate the long-term effects of electrical stimulation of RSAs. Results: Study 1: Electrical stimulation of RSAs evoked phantom touch sensations in the deafferented limb, and significantly alleviated PLP (p  < 0.05). Study 2: PLP was alleviated more after electrical stimulation on RSAs compared with control electrical stimulation (p  < 0.05). However, the analgesic effects of electrical stimulation on RSAs were observed only in the short term, not in the long term (p  > 0.05). Conclusions: Electrical stimulation of RSAs not only evoked phantom touch sensation but also alleviated PLP in the short term. The results indicate that electrical stimulation of RSAs may provide a useful practical rehabilitation technique for PLP. Future studies will be required to clarify the mechanisms underlying immediate PLP alleviation via electrical stimulation of RSAs. Show more

Keywords: Phantom limb pain, electrical stimulation, referred sensation, brachial plexus avulsion

DOI: 10.3233/RNN-201132

Citation: Restorative Neurology and Neuroscience, vol. 39, no. 2, pp. 101-110, 2021

Authors: Yeh, Tzu-Yin | Liu, Pei-Hsin

Article Type: Research Article

Abstract: Background: In the cranial cavity, a space-occupying mass such as epidural hematoma usually leads to compression of brain. Removal of a large compressive mass under the cranial vault is critical to the patients. Objective: The purpose of this study was to examine whether and to what extent epidural decompression of the rat primary somatosensory cortex affects the underlying microvessels, spiny stellate neurons and their afferent fibers. Methods: Rats received epidural decompression with preceding 1-week compression by implantation of a bead. The thickness of cortex was measured using brain coronal sections. The permeability of blood-brain barrier (BBB) …was assessed by Evans Blue and immunoglobulin G extravasation. The dendrites and dendritic spines of the spiny stellate neurons were revealed by Golgi-Cox staining and analyzed. In addition, the thalamocortical afferent (TCA) fibers in the cortex were illustrated using anterograde tracing and examined. Results: The cortex gradually regained its thickness over time and became comparable to the sham group at 3 days after decompression. Although the diameter of cortical microvessels were unaltered, a transient disruption of the BBB was observed at 6 hours and 1 day after decompression. Nevertheless, no brain edema was detected. In contrast, the dendrites and dendritic spines of the spiny stellate neurons and the TCA fibers were markedly restored from 2 weeks to 3 months after decompression. Conclusions: Epidural decompression caused a breakdown of the BBB, which was early-occurring and short-lasting. In contrast, epidural decompression facilitated a late-onset and prolonged recovery of the spiny stellate neurons and their afferent fibers. Show more

Keywords: Decompression, stellate neuron, thalamocortical fiber, BBB, dendritic spine, somatosensory cortex

DOI: 10.3233/RNN-201085

Citation: Restorative Neurology and Neuroscience, vol. 39, no. 2, pp. 111-127, 2021

Authors: Liu, Yaping | Qu, Mingwei | Wang, Nan | Wang, Limin

Article Type: Research Article

Abstract: Background: Acute cerebral infarction is a clinically common and critical disease which seriously endangers the life and safety of elderly patients. Evidence-based nursing is an effective way of nursing and has great significance in improving the neurological function and quality of life of patients. In China, evidence-based nursing has been highlighted and highly developed in recent decades. Objectives: This research aimed to investigate the effect of evidence-based nursing on the recovery of neurological function and serum inflammatory cytokines in patients with acute cerebral infarction. Methods: A total of 116 patients with acute cerebral infarction were randomly …divided into two groups: the control group patients (n  = 58) received conventional nursing, while the intervention group patients (n  = 58) received evidence-based nursing intervention. National Institutes of Health Stroke Scale (NIHSS), Fugl-Meyer assessment (FMA) and activities of daily living (ADL) scores, as well as serum TNF-α and IL-6 levels were evaluated and compared between the two groups. Results: NIHSS scores in the intervention group were significantly lower than the control group. FMA and ADL scores in the intervention group were significantly higher than the control group. TNF-α and IL-6 levels in the serum of the intervention group were significantly lower than the control group. Conclusions: In conclusion, evidence-based nursing has a positive effect on the treatment of patients with acute cerebral infarction, which decreases the level of serum inflammatory cytokines and contributes to the recovery of neurological function, motor function and activities of daily living. Show more

Keywords: Acute cerebral infarction, evidence-based nursing, TNF-α , IL-6, quality of life, neurological function

DOI: 10.3233/RNN-201080

Citation: Restorative Neurology and Neuroscience, vol. 39, no. 2, pp. 129-137, 2021

Authors: Okuda, Yoshinobu | Aoike, Futoshi | Matsuzaki, Jo | Shiraishi, Shoichi | Sugiyama, Shintaro | Yoshida, Tomoko | Kitamura, Emi | Nishida, Fukuko | Tanaka, Natsuki | Sugiyama, Yasuko | Enami, Tomomi | Yanagihara, Takehiko

Article Type: Research Article

Abstract: Background: Functional recoveries after rehabilitation of patients with branch atheromatous disease (BAD) have not been well investigated, however, clinical category of cerebral infarction including BAD itself could be a potential predictive factor for functional outcome. Objective: To describe characteristics of functional recoveries of patients with BAD through comparison with other types of cerebral infarction. Methods: We retrospectively compared outcomes of patients with BAD (N = 222), cardioembolic cerebral infarction (CE: N = 177) and atherothrombotic cerebral infarction (AT: N = 219) by using functional independence measure (FIM) and FIM effectiveness (the proportion of potential for improvement achieved). Results: Univariate analysis …showed that FIM on discharge was comparable among three types of cerebral infarction, but that FIM effectiveness in patients with BAD was significantly higher than those with CE or AT. Stratified analysis revealed higher FIM effectiveness in patients with BAD compared to patients with CE or AT, if they were male, younger (≤72 years) or had supratentorial brain lesions. Multiple regression analysis demonstrated that location of the brain lesion (supratentorial vs infratentorial) and gender (male vs female) were significantly associated with FIM on discharge, and that cognitive function on admission as well as gender were significantly associated with FIM effectiveness in patients with BAD, but not in patients with CE or AT. Conclusions: Outcomes after rehabilitation of patients with BAD may be characterized by better functional improvement, especially if patients are male, relatively younger or with supratentorial lesions. The impact and the type of factors related to functional recoveries of patients with BAD may be different from other types of stroke. The present study suggested that clinical category of stroke should be taken into consideration in prediction of outcomes and planning of rehabilitation management. Show more

Keywords: Branch atheromatous disease, cerebral infarction, functional recovery, rehabilitation, predictive factors, stroke

DOI: 10.3233/RNN-211163

Citation: Restorative Neurology and Neuroscience, vol. 39, no. 2, pp. 139-147, 2021

Authors: Abuirmeileh, Amjad N. | Abuhamdah, Sawsan M. | Ashraf, Asser | Alzoubi, Karem H.

Article Type: Research Article

Abstract: Background: Caffeine and taurine, which possess neuro-modulatory activity happen to be consumed together as part of the constituents of energy drinks, could have beneficial effects and prevent neuronal deterioration in Parkinson’s disease (PD). Objective: This study aimed to investigate behavioral and neurochemical effects of these two agents in an animal model of PD at two time points to evaluate possible neuro-protective or neuro-modulatory effects. Methods: Stereotaxic injection of 6-hydroxydopamine (6-OHDA) in rat striatum was used to model PD-like behavior in animals. Motor behavior was assessed by a characteristic rotation behavior response to the apomorphine challenge and …dopamine levels in the striatum were quantified using HPLC-ED. Results: A reduction in apomorphine induced rotations following administration of caffeine and/or taurine as compared to the untreated lesioned group (controls) was shown. Significant decreases in dopamine levels were also seen in the ipsilateral side of 6-OHDA group, this effect was not significantly reversed in caffeine and taurine treated groups. Treatments partially restored the content of DA levels in the lesioned striatum. Conclusions: Current results demonstrated beneficial effects for the combination of caffeine and taurine in PD animal model, suggesting that consumption of both agents could be a new added therapeutic target for Parkinson’s disease prevention and treatment. Show more

Keywords: Caffeine, taurine, 6-hydroxydopamine, rat, Parkinson’s disease

DOI: 10.3233/RNN-201131

Citation: Restorative Neurology and Neuroscience, vol. 39, no. 2, pp. 149-157, 2021