Clinical Hemorheology and Microcirculation - Volume 5, issue 2

Article Type: Editorial

DOI: 10.3233/CH-1985-5211

Citation: Clinical Hemorheology and Microcirculation, vol. 5, no. 2, pp. 1-3, 1985

Authors: Ernst, E. | Roloff, Ch. | Magyarosy, I. | Matrai, A.

Article Type: Research Article

Abstract: Nineteen patients with the confirmed diagnosis of ankylosing spondylitis have been investigated for hemorheological abnormalities (serum, plasma and whole blood viscosities, hematocrit, red cell filterability and aggregation, fibrinogen, ESR). Compared to matched controls these variables showed significant deterioration in patients. The pathophysiological relevance of the findings would seem to merit further investigation.

Keywords: haemorheology, blood viscosity, plasma viscosity, red cell aggregation, red cell filterability, ankylosing spondylitis, rheumatic disease

DOI: 10.3233/CH-1985-5201

Citation: Clinical Hemorheology and Microcirculation, vol. 5, no. 2, pp. 109-114, 1985

Authors: Bogar, L. | Matrai, A. | Walker, R.T. | Flute, P.T. | Dormandy, J.A.

Article Type: Research Article

Abstract: The haemorheological effect of a specific 5-hydroxy-tryptamine antagonist (ketanserin) was studied in 15 patients with severe ischaemic disease, given a continuous infusion for 7 days. The results were compared to a placebo infusion in 10 similar patients. The whole blood viscosity decreased significantly by 11–21% depending on the shear rate applied (0.7, 2.4 and 95 s−1 ) during active treatment. This viscosity decrease can be attributed to haemodilution, since the blood viscosity data corrected to a standard haematocrit did not show any significant change. The haemodilution may have been partly due to the very marked effect of ketanserin on physical …properties of white cells, manifested by a 53% decrease in the number of “clogging particles” 1n the blood. The red cell deformability index, determined as the transit time of red cells relative to the suspending medium, was also improved by ketanserin. Show more

Keywords: 5-HT2 receptor antagonist, ketanserin, blood viscosity, ischaemic disease, haemodilution, clogging particles, red cell deformability

DOI: 10.3233/CH-1985-5202

Citation: Clinical Hemorheology and Microcirculation, vol. 5, no. 2, pp. 115-121, 1985

Authors: Mendlowitz, Milton

Article Type: Research Article

Abstract: Many of the large number of variables within the mammalian circulation are discussed. Certain measurements can be made directly in animals and also in man but are subject to inaccuracy of technique and must be analyzed statistically at all times. Inferential measurements which are drawn from the relationship between direct measurements must always have specific frames of reference within which they may be reasonably accurate but beyond which they become increasingly meaningless. Such frames of reference and their limits must always be tested and the results, again, estimated statistically and accepted only within the tested mathematical range. Qualitative inferences, of …course, can be drawn but are not subject to statistical evaluation and causality may remain problematical in any statistically significant measurement. Show more

Keywords: Cardiovascular Hydraulics

DOI: 10.3233/CH-1985-5203

Citation: Clinical Hemorheology and Microcirculation, vol. 5, no. 2, pp. 123-135, 1985

Authors: Stuart, J. | Stone, P.C.W. | Bareford, D. | Caldwell, N.M. | Davies, J.E. | Baar, S.

Article Type: Research Article

Abstract: Erythrocyte filtration, as measured by the initial-flow-rate Hemorheometre technique, showed a highly significant correlation (r = 0.603, P < 0.001) with even a small number of contaminating leucocytes (mean 0.08 × 109 /l, SEM 0.01) in 29 erythrocyte test suspensions. Failure to reduce leucocyte contamination to <0.025 × 109 /l caused falsely abnormal erythrocyte filtration values. Centrifugation failed to remove sufficient leucocytes from anaemic blood specimens but pre-filtration through Imugard IG500 cotton wool reduced leucocyte contamination to <0.025 × 109 /l in 73 of 74 blood samples. There was no evidence for selective cotton wool trapping of erythrocyte sub-populations to …an extent that affected rheological measurements obtained by the Hemorheometre, the Ektacytometer, or by adhesion of erythrocytes to cultured human vascular endothelium. Show more

Keywords: Rheology, Erythrocyte filtration, Leucocyte removal

DOI: 10.3233/CH-1985-5204

Citation: Clinical Hemorheology and Microcirculation, vol. 5, no. 2, pp. 137-147, 1985

Authors: Francis, Deborah A. | Francis, J.L. | Roath, O.S.

Article Type: Short Communication

Keywords: Nifedipine, calcium antagonists, erythrocyte deformability

DOI: 10.3233/CH-1985-5205

Citation: Clinical Hemorheology and Microcirculation, vol. 5, no. 2, pp. 149-153, 1985

Authors: Caimi, Gregorio | Galluzzo, Aldo | Giordano, Carla | Caruso, Calogero | Capobianco, Diego | Sarno, Antonio

Article Type: Short Communication

Keywords: IDDM, HLA antigens, haemorheology

DOI: 10.3233/CH-1985-5206

Citation: Clinical Hemorheology and Microcirculation, vol. 5, no. 2, pp. 155-158, 1985

Authors: Stuart, John

Article Type: Review Article

Abstract: The design of rheological studies is of critical importance for the demonstration of a true difference in erythrocyte deformability between patient and control groups. Principles that form the basis of good study design include an adequate number of patients, concurrent study of patients and matched controls, elimination of acute phase reactants, explanation of results in relation to known determinants of erythrocyte deformability, study of a representative blood sample, inclusion of a quality assurance programme, appropriate statistical analysis, and the use of a combination of rheological instruments that measure different aspects of erythrocyte deformability. These principles should routinely be applied when …designing, or evaluating, rheological studies. Show more

Keywords: Rheology, Erythrocyte deformability, Quality assurance

DOI: 10.3233/CH-1985-5207

Citation: Clinical Hemorheology and Microcirculation, vol. 5, no. 2, pp. 159-169, 1985

Authors: Dintenfass, L.

Article Type: Letter

Keywords: Red Cell Aggregation, Blood Viscosity, Zero Gravity Experiment, Slit-Capillary Photo-viscometer, Red Cell Rouleaux, Red Cell Semimentation

DOI: 10.3233/CH-1985-5208

Citation: Clinical Hemorheology and Microcirculation, vol. 5, no. 2, pp. 171-172, 1985

Authors: Benner, Klaus-U. | Nordt, Frank J.

Article Type: Abstract

DOI: 10.3233/CH-1985-5209

Citation: Clinical Hemorheology and Microcirculation, vol. 5, no. 2, pp. 173-175, 1985