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Price: EUR 185.00Authors: Jayavanth, Sanjay | Singh, Megha
Article Type: Research Article
Abstract: The erythrocyte aggregation and deformability of blood samples obtained from normal subjects and malaria patients are determined by microscopic imaging and laser aggregometry techniques, and optical hemorheometer, respectively. By these techniques several parameters are determined but four parameters, aggregate sedimentation velocity (ASV), effective number of cells (ENC), process completion time (PCT) and mean filtration time (MFT), show significant variation in malaria patients compared to that of healthy subjects. For malaria severity analysis artificial neural network (ANN), based on feedforward‐error back‐propagation algorithm in a supervisory training mode is proposed. This network is first trained for different number of epochs ranging from …20 to 50 by set of patterns and at 30 epochs training session the minimum mean square error (MSE) between desired and actual output is obtained. By applying the same procedure the test patterns belonging to normal, non‐severe, severe, and highly severe malaria (NSM, SM and HSM) are identified. The results show that malaria with high severity is classified accurately (100%). The success of classification for non‐severe and mildly‐severe malaria ranges from 60% to 80%. Show more
Keywords: Malaria, erythrocyte aggregation, deformability, artificial neural network, severity classification
Citation: Clinical Hemorheology and Microcirculation, vol. 29, no. 3-4, pp. 457-468, 2003
Authors: Futrakul, Narisa | Siriviriyakul, Prasong | Panichakul, Tasanee | Butthep, Punnee | Patumraj, Suthiluk | Futrakul, Prasit
Article Type: Research Article
Abstract: Glomerular endothelial cell dysfunction (GED) with defective release of vasodilator has been delineated in nephrosis (NS) in vivo and in vitro studies. In NS with focal segmental glomerulosclerosis (FSGS), an immunocirculatory balance may be impaired due to defective anti‐inflammatory cytokine. This study aimed at simultaneous determination of both proinflammatory cytokine (tumor necrosis factor alpha) and an anti‐inflammatory cytokine (interleukin‐10) in NS with FSGS. An endothelial cell cytotoxicity (ECC) was also examined using nephrotic serum. It was shown that (1) the initial endothelial cell cytotoxicity was significantly different from the control, (2) ratio between tumor necrosis alpha and interleukin‐10 was significantly …elevated, and (3) intrarenal hemodynamics was changed significantly. Show more
Keywords: Glomerular endothelial dysfunction, cytokine, endothelial cell cytotoxicity, nephrosis, focal segmental glomerulo‐ sclerosis
Citation: Clinical Hemorheology and Microcirculation, vol. 29, no. 3-4, pp. 469-473, 2003
Article Type: Other
Citation: Clinical Hemorheology and Microcirculation, vol. 29, no. 3-4, pp. 475-482, 2003
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