Clinical Hemorheology and Microcirculation - Volume 11, issue 1-2

Authors: Hiruma, H. | Ito, M. | Shio, H. | Uyesaka, N.

Article Type: Research Article

Abstract: Effect of contrast media (CM) on red blood cell (RBC) filterability was studied using a newly developed nickel mesh filtration method. The impact of CM osmolality, viscosity and iodine content on RBC filterability in this system was analyzed. Under isotonic conditions, iothalamate (48 mgI/ml, 1.3 cp) and low osmolality CM, iohexol (101 mgI/ml, 1.8 cp) did not cause any changes in RBC morphology. The RBC suspension of iothalamate was more filterable than that of iohexol because of low viscosity. However, under equal viscosity (iodine content) conditions, iothalamate caused shape change and marked decreases in RBC filterability with a small increase …in viscosity (iodine content) from 1.3 cp to 1.7 cp (48 mgI/ml to 98 mgI/ml). This change in viscosity (iodine content) corresponded to a remarkable increase in osmolality from 300 mOsm/kgH2 O to 588 mOsm/kgH2 O. Under similar conditions, iohexol did not induce any discernible shape changes and resulted in a small decrease in filterability. The present study clearly showed that the osmotic effect of CM on RBC filterability is more predominant than the effects of viscosity and iodine content. Show more

Keywords: contrast media, red cell filterability, osmolality, viscosity, iodine, iohexol

DOI: 10.3233/CH-1991-111-211

Citation: Clinical Hemorheology and Microcirculation, vol. 11, no. 1-2, pp. 91-105, 1991

Authors: Ernst, E. | Resch, K.L. | SchmidIechner, Ch. | Paulsen, H.F. | Saradeth, T.

Article Type: Research Article

Abstract: Fourty four patients with cholesterol levels above 250 mg/dl were randomized into two groups receiving either n-3 fatty acids (3*2 capsules daily) or placebo for 24 days. Hematocrit, blood and plasma viscosity were taken at baseline, after 12 and 24 days. The results show that blood viscosity falls in both groups. The decline is faster and stronger in the n-3 supplemented group. There is no change in plasma viscosity in either group. Hematocrit falls slightly in the n-3 group. The findings confirm earlier data but are obtained with a more rigorous study design. In conclusion we feel that n-3 fatty …acids have a strong potential for normalizing blood rheology and should be tested clinically under this aspect. Show more

Keywords: n-3 fatty acids, fish oil, blood viscosity, diet, hemorheology

DOI: 10.3233/CH-1991-111-212

Citation: Clinical Hemorheology and Microcirculation, vol. 11, no. 1-2, pp. 107-112, 1991

Authors: Zhu, J.-C. | Stone, P.C.W. | Stuart, J.

Article Type: Research Article

Abstract: An erythrocyte control preparation for quality assurance purposes would be of considerable value in rheological studies of erythrocyte filterability (deformability). Normal human erythrocytes stored at 4°C in citrate-phosphate-dextrose or saline-adenine-glucose-mannitol appeared to be rheologically stable for 4 weeks when tested using the Hemorheometre or Cell Transit Analyser but, after 2–3 weeks' storage, an increasing sub-population of pore clogging erythrocytes was detected by the St. George's Filtrometer. In contrast, a commercial preparation of stabilised human red blood cells (Coulter SH-RBC) was found to be more stable rheologically, as tested by all three instruments, for up to 6 weeks and thus has …potential as a rheological control preparation. Show more

Keywords: Rheology, erythrocyte deformability, quality assurance

DOI: 10.3233/CH-1991-111-213

Citation: Clinical Hemorheology and Microcirculation, vol. 11, no. 1-2, pp. 113-120, 1991

Authors: Başkurt, O.K. | Levi, E. | Çağlayan, S. | Dikmenoğlu, N. | Üçer, O. | Güner, R. | Yörükan, S.

Article Type: Research Article

Abstract: Coronary resistances of dogs with normal coronaries were measured before and after the hematocrit values were increased by exchange transfusion of packed red blood cell suspensions. Coronary resistances increased about 9% in this group. In a second group of dogs, experiments were performed after the coronary arteries were critically stenosed. The changes in coronary resistances were more prominent in the critical stenosis group. Blood viscosity measured at a hematocrit of 45% and erythrocyte deformability indexes were also increased in the coronary sinus blood after the exchange transfusion of packed cells. These findings imply that there is a close relationship between …the rheologic properties of blood and coronary circulation. This relationship may include a positive feed-back, which will result in detrimental etTects on blood rheologic parameters. Show more

Keywords: Coronary circulation, hematocrit, erythrocyte deformability

DOI: 10.3233/CH-1991-111-214

Citation: Clinical Hemorheology and Microcirculation, vol. 11, no. 1-2, pp. 121-127, 1991

Authors: Ernst, E. | Marschall, M.

Article Type: Short Communication

Keywords: leukocytes, exercise, microcirculation, acute phase reaction,

DOI: 10.3233/CH-1991-111-215

Citation: Clinical Hemorheology and Microcirculation, vol. 11, no. 1-2, pp. 129-132, 1991

Authors: Vayà, Amparo | Martinez, Marcial | Aznar, Justo

Article Type: Letter

Keywords: whole blood filterability, erythrocyte deformability, ischemia

DOI: 10.3233/CH-1991-111-216

Citation: Clinical Hemorheology and Microcirculation, vol. 11, no. 1-2, pp. 133-135, 1991

Authors: Whittingstall, P.

Article Type: Letter

DOI: 10.3233/CH-1991-111-217

Citation: Clinical Hemorheology and Microcirculation, vol. 11, no. 1-2, pp. 137-139, 1991

Article Type: Other

DOI: 10.3233/CH-1991-111-218

Citation: Clinical Hemorheology and Microcirculation, vol. 11, no. 1-2, pp. 141-141, 1991