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Biorheology is an international interdisciplinary journal that publishes research on the deformation and flow properties of biological systems or materials. It is the aim of the editors and publishers of
Biorheology to bring together contributions from those working in various fields of biorheological research from all over the world. A diverse editorial board with broad international representation provides guidance and expertise in wide-ranging applications of rheological methods to biological systems and materials.
The aim of biorheological research is to determine and characterize the dynamics of physiological processes at all levels of organization. Manuscripts should report original theoretical and/or experimental research promoting the scientific and technological advances in a broad field that ranges from the rheology of macromolecules and macromolecular arrays to cell, tissue and organ rheology. In all these areas, the interrelationships of rheological properties of the systems or materials investigated and their structural and functional aspects are stressed.
The scope of papers solicited by
Biorheology extends to systems at different levels of organization that have never been studied before, or, if studied previously, have either never been analyzed in terms of their rheological properties or have not been studied from the point of view of the rheological matching between their structural and functional properties. This biorheological approach applies in particular to molecular studies where changes of physical properties and conformation are investigated without reference to how the process actually takes place, how the forces generated are matched to the properties of the structures and environment concerned, proper time scales, or what structures or strength of structures are required.
Biorheology invites papers in which such 'molecular biorheological' aspects, whether in animal or plant systems, are examined and discussed. While we emphasize the biorheology of physiological function in organs and systems, the biorheology of disease is of equal interest. Biorheological analyses of pathological processes and their clinical implications are encouraged, including basic clinical research on hemodynamics and hemorheology.
In keeping with the rapidly developing fields of mechanobiology and regenerative medicine,
Biorheology aims to include studies of the rheological aspects of these fields by focusing on the dynamics of mechanical stress formation and the response of biological materials at the molecular and cellular level resulting from fluid-solid interactions. With increasing focus on new applications of nanotechnology to biological systems, rheological studies of the behavior of biological materials in therapeutic or diagnostic medical devices operating at the micro and nano scales are most welcome.
Abstract: The viscosity of whole blood (WB), plasma (P), and packed cells (PC) was measured in a Wells-Brookfield cone plate viscometer on blood from dogs undergoing surgical shock and hemodilution with different plasma substitutes and on human ACD-blood diluted in vitro to comparable concentrations of colloids. Erythrocyte sedimentation rate (ESR) and microscopic red cell aggregate count were used as in vitro indices of red cell aggregation. During three hours of intestinal shock WB viscosity increased by 20 %, hematocrit increased from 50.9 to 59. 1 %, P viscosity was unchanged and PC viscosity increased by 6 %. When compared at equal…hematocrit drop, Ringer’s acetate decreased WB viscosity more than albumin, ACD-plasma, dextran 70 and gelatin in this order both on blood diluted in vitro and in vivo. Since the duration of volume expansion in vivo after Ringer’s solution was very transient the absolute decrease of viscosity was less than that observed after all other solutions except gelatin. P viscosity increased with dextran 70, was unchanged with ACD-plasma, dextran 40, and gelatin and decreased with albumin and Ringer’s acetate dilution. A marked red cell aggregation occurred with dextran 70 and gelatin with increasing concentration. No aggregation of red cells was seen with dextran 40, albumin, or Ringer’s acetate. It is concluded that lasting hemodilution in vivo is best achieved with albumin and dextran 40 based on their viscosity influences, volume expansion duration and their lack of red cell aggregation properties.
vol. 17, no. 1-2, pp. 9-16, 1980
Abstract: A Couette viscometer with axial flow is proposed which allows blood to be exposed to defined shear stresses of short duration. A prototype of this viscometer is tested. By measurements and simple calculations the range of application is established. Measurements with blood show the possibility to control the flow conditions which may lead to haemolysis.
vol. 17, no. 1-2, pp. 17-24, 1980
Abstract: A capillary viscosmeter is described which allows measurement of the shear rate dependency of fresh blood viscosity at low shear rates. The instrument has been used in a preliminary study to evaluate differences between fresh and EDTA anticoagulated blood. In a shear rate range of 0.5 to 1.3 sec−1 the viscosity of fresh blood is more strongly dependent on hematocrit than is the viscosity of EDTA anticoagulated blood. Also, the viscosity of anticoagulated blood is more sensitive to day-to-day variations than is that of fresh blood. For some subjects, such variations may amount to as much as 30%.
vol. 17, no. 1-2, pp. 25-35, 1980
Abstract: Enzymes are widely used to remove selectively various stress bearing components of connective tissues before, during or after application of stress. This paper surveys and critically reviews these techniques.
vol. 17, no. 1-2, pp. 45-50, 1980
Abstract: Crosslinking of collagen is a prerequisite for the collagen fibers to withstand the physical stresses to which they are exposed. Significant progress has been made in understanding the functional groups on the molecule which are involved in the formation of crosslinks. Chemical agents, in particular bifunctional aldehydes such as glutaraldehyde, have found applications in the area of bioprostheses. They increase the resistance of collagen to biological degradation while increasing its mechanical resistance and decreasing its immunogenicity. It is to be expected that our increasing understanding of the molecular structure of collagen will allow us to further modulate its process of…biosynthesis and turnover as well as to benefit from the use of chemically modified collagen fibers in the development of novel bioprostheses.
vol. 17, no. 1-2, pp. 51-82, 1980