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Biorheology is an international interdisciplinary journal that publishes research on the deformation and flow properties of biological systems or materials. It is the aim of the editors and publishers of
Biorheology to bring together contributions from those working in various fields of biorheological research from all over the world. A diverse editorial board with broad international representation provides guidance and expertise in wide-ranging applications of rheological methods to biological systems and materials.
The aim of biorheological research is to determine and characterize the dynamics of physiological processes at all levels of organization. Manuscripts should report original theoretical and/or experimental research promoting the scientific and technological advances in a broad field that ranges from the rheology of macromolecules and macromolecular arrays to cell, tissue and organ rheology. In all these areas, the interrelationships of rheological properties of the systems or materials investigated and their structural and functional aspects are stressed.
The scope of papers solicited by
Biorheology extends to systems at different levels of organization that have never been studied before, or, if studied previously, have either never been analyzed in terms of their rheological properties or have not been studied from the point of view of the rheological matching between their structural and functional properties. This biorheological approach applies in particular to molecular studies where changes of physical properties and conformation are investigated without reference to how the process actually takes place, how the forces generated are matched to the properties of the structures and environment concerned, proper time scales, or what structures or strength of structures are required.
Biorheology invites papers in which such 'molecular biorheological' aspects, whether in animal or plant systems, are examined and discussed. While we emphasize the biorheology of physiological function in organs and systems, the biorheology of disease is of equal interest. Biorheological analyses of pathological processes and their clinical implications are encouraged, including basic clinical research on hemodynamics and hemorheology.
In keeping with the rapidly developing fields of mechanobiology and regenerative medicine,
Biorheology aims to include studies of the rheological aspects of these fields by focusing on the dynamics of mechanical stress formation and the response of biological materials at the molecular and cellular level resulting from fluid-solid interactions. With increasing focus on new applications of nanotechnology to biological systems, rheological studies of the behavior of biological materials in therapeutic or diagnostic medical devices operating at the micro and nano scales are most welcome.
Abstract: Mathematical models for conventional transport of physiological fluids, are explored analytically including the characteristics and influences of the boundaries and media through which the flow occurs. The flow in fine capillaries with permeable walls was considered on the basis of some variants of the Krogh model [Krogh Physiol. 52 (1919), 391] for capillary-tissue exchange and the Wiederhielm [In: Physical Bases of Circulatory Transport: Regulation and Exchange (Edited by Reeve and Guyton ) p. 313. Saunder, 1967, J. Gen. Physiol. 52 (1968), Suppl. Pt. 2, 295] model for the extravascular circulation. Filtration…from a cylindrical capillary into a concentrically surrounding tissue space: flow from a capillary into the tissue across a thin membrane; filtration from a rectangular, a cylindrical and a conical channel, bounded by a permeable material of uniform or regionally different permeability. and transcapillary fluid exchange were analyzed in some detail. For biological systems, which are characterized by low permeability, the calculations show that, independent of detailed geometry, any factor which produces a nonlinear distribution of pressure in the capillary will increase the filtration efficiency per unit of permeable area. Nonlinear pressure distributions will arise, for example, due to an asymmetry of geometrical structure or as a result of interaction between red cell and wall during cell movement down the capillary. The filtration process is adequately described by a linear filtration law (the Starling relationship). Non-linear laws are only of minor interest. In the systems considered the influence of velocity slip on filtration is negligible. The proposed models behave in such a way that the total amount of filtered fluid for a given capillary cannot exceed some limiting value. Thin membranes of low permeability on sufficiently thick layers of the tissue reduce the pressure gradient in the tissue to a value very small as compared with the pressure gradient of blood flow in the capillary. The results obtained closely correspond to the microcirculation with respect to permeation rates and pressure distribution in the tissue. It was found that the system responds stably to changes in pressure, changes in rate of lymph flow etc. because of mutual compensation between the factors involved.
Abstract: The continuum theory of blood flow developed by Kline and Allen is used to determine two constitutive parameters of blood, the vortex viscosity and the volume averaged radius of gyration, under oscillatory flow conditions at constant flow amplitudes. For a wide range of hematocrits, suspending medium viscosities, and tube sizes. these parameters were found to be frequency invariant.
Abstract: It could be shown experimentally that human plasma as well as human blood behave rheologically like visco-elastic fluids: they both show a significant friction reduction in turbulent pipe-flow. Furthermore, at extremely low shear-rates blood viscosity becomes constant (zero-shear viscosity). Thus, the hypothesis that blood has a yield shear–stress cannot be maintained. The temperature dependence of plasma viscosity could be mathematically described based on the results of experiments. For diagnostic purposes, plasma and blood viscosity are correlated to normal values at selected shear-rates. The clinical significance of the measured values will be shown by the examples of myocardial infarction and…von-Willebrand–Jürgens syndrome.