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Biorheology is an international interdisciplinary journal that publishes research on the deformation and flow properties of biological systems or materials. It is the aim of the editors and publishers of
Biorheology to bring together contributions from those working in various fields of biorheological research from all over the world. A diverse editorial board with broad international representation provides guidance and expertise in wide-ranging applications of rheological methods to biological systems and materials.
The aim of biorheological research is to determine and characterize the dynamics of physiological processes at all levels of organization. Manuscripts should report original theoretical and/or experimental research promoting the scientific and technological advances in a broad field that ranges from the rheology of macromolecules and macromolecular arrays to cell, tissue and organ rheology. In all these areas, the interrelationships of rheological properties of the systems or materials investigated and their structural and functional aspects are stressed.
The scope of papers solicited by
Biorheology extends to systems at different levels of organization that have never been studied before, or, if studied previously, have either never been analyzed in terms of their rheological properties or have not been studied from the point of view of the rheological matching between their structural and functional properties. This biorheological approach applies in particular to molecular studies where changes of physical properties and conformation are investigated without reference to how the process actually takes place, how the forces generated are matched to the properties of the structures and environment concerned, proper time scales, or what structures or strength of structures are required.
Biorheology invites papers in which such 'molecular biorheological' aspects, whether in animal or plant systems, are examined and discussed. While we emphasize the biorheology of physiological function in organs and systems, the biorheology of disease is of equal interest. Biorheological analyses of pathological processes and their clinical implications are encouraged, including basic clinical research on hemodynamics and hemorheology.
In keeping with the rapidly developing fields of mechanobiology and regenerative medicine,
Biorheology aims to include studies of the rheological aspects of these fields by focusing on the dynamics of mechanical stress formation and the response of biological materials at the molecular and cellular level resulting from fluid-solid interactions. With increasing focus on new applications of nanotechnology to biological systems, rheological studies of the behavior of biological materials in therapeutic or diagnostic medical devices operating at the micro and nano scales are most welcome.
Abstract: Sedimentation and aggregation of red cells were studied in the freshly shed blood, anticoagulated with EDTA, of 88 donors. including cancer and vascular patients. Tests were carried out in Westergren tubes at room temperature and at 37° and 40°C. Aggregation of red cells was estimated from ESR’s corrected for plasma viscosity and adjusted to 30 per cent haematocrit. Sedimentation rates and aggregation of red cells increase at higher temperatures. The degree of this effect depends on the type of disease, on the type of ABO blood group, and on the interplay between contradictory actions of albumin and fibrinogen. A negative correlation…between the temperature coefficient of aggregation of red cells and the fibrinogen concentration is shown by patients with vascular diseases and, to a much higher measure, by cancer patients of blood group A only. Temperature coefficient of aggregation of red cells appears to be a much more specific parameter than the aggregation of red cells.
vol. 10, no. 3, pp. 383-391, 1973
Abstract: In the present study, an investigation was into the changes in viscoelasticity of the clot formed during the process of blood coagulation of normal subjects and of patients with a variety of disease, in an effort to elucidate the rheological aspect of a thrombus formation. Dynamic viscoelasticity was measured by the viscoelastorecorder and was shown by absolute values, namely dynamic elastic modulus (E′) and loss modulus (E″). Experimental conditions were: temperature, 25.0°C; oscillation of outer cylinder, 3 c/s, amplitude; 60 μ m from peak to peak; and blood samples used diluted to 66.7 per cent of the original…by adding citrate and CaCl2 solutions which were used as an anticoagulant and for recalcification, respectively. Results of experiment were as follows: (1) Average saturated dynamic elastic modulus (E′s) and loss modulus (E″s) of normal subjects were 3393 and 252 dyn/cm2 , respectively. High viscoelasticity of blood clot was often recorded in patients with connective tissue disease, neoplasm, hematological disease (polycythemia vera and chronic granulocytic leukemia), infection and diabetes mellitus. (2) Investigation of causative factors of high E′s level. In high E′s group of patients, hematocrit was lower than that of the groups of which E′s was within normal limits, however, platelet count, plasma viscosity and erythrocyte sedimentation rate elicited high levels. Also, high E′s level was accompanied by high levels of maximum clotting gradient and E″s. (3) Correlation of factors related to clot strength was studied. Good correlations were found in E′s vs MCG, E′s vs plasma fibrinogen, E′s vs E″s, and tan δ vs E″s. (4) Effects of platelet on clot strength. In platelet rich plasma, levels of MCG, MCG′, E′s, E″s and tan δ were higher than those of whole blood or platelet poor plasma. It is of interest to note that tan δ was influenced by platelet count.
vol. 10, no. 3, pp. 411-424, 1973
Abstract: A fluid mechanical model for the interpretation of the intestinal activity is proposed. The intestinal contents are assumed to behave rheologically as a power law fluid. The intraluminal pressures are obtained in terms of the parameters characterizing the power law fluid and the geometry and the kinematics of the intestinal wall. The differences between peristaltic movement and isolated contraction of the wall are discussed.
vol. 10, no. 3, pp. 431-440, 1973
Abstract: In order to understand colonic activity, the rheological properties of the colonic contents are needed. A suitable tube viscometer was constructed and viscometric measurements on human feces were performed. The results indicate that, at sufficiently high shear rates, the feces behave as a power law fluid, i.e. Shear Stress ∼ (Shear Rate)m . For these shear rates the exponent m was approximately the same for all samples tested, regardless of their consisLcncy, and equal to 0.25.
vol. 10, no. 3, pp. 441-445, 1973
Abstract: Using the vitalmicrospectrophotometric technique the protein content was measured in exposed rat mesentery at 280 nm absorbance. In intravascular circulating blood plasma there was a linear relationship between the protein content and the measured absorbance which proved the methodical reliability of the technique. In cellfree perivascular tissue the protein content was higher around venules than around capillaries and arterioles. There was a decrease in the protein content of the interstitial tissue with increasing distance from the vessel wall. This concentration gradient is highest around venules. A change in the colloidosmotic pressure of blood leads to a change of the protein…content of the perivascular tissue. Accordingly a decrease in colloidosmotic pressure will result in loss of tissue protein while an increase in plasma protein will lead to an outward shift of proteins into the perivascular tissue.
vol. 10, no. 3, pp. 447-451, 1973