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Bio-Medical Materials and Engineering - Volume 28, issue s1

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Price: EUR 245.00
Impact Factor 2024: 1.0

The aim of Bio-Medical Materials and Engineering is to promote the welfare of humans and to help them keep healthy. This international journal is an interdisciplinary journal that publishes original research papers, review articles and brief notes on materials and engineering for biological and medical systems.

Articles in this peer-reviewed journal cover a wide range of topics, including, but not limited to: Engineering as applied to improving diagnosis, therapy, and prevention of disease and injury, and better substitutes for damaged or disabled human organs; Studies of biomaterial interactions with the human body, bio-compatibility, interfacial and interaction problems; Biomechanical behavior under biological and/or medical conditions; Mechanical and biological properties of membrane biomaterials; Cellular and tissue engineering, physiological, biophysical, biochemical bioengineering aspects; Implant failure fields and degradation of implants. Biomimetics engineering and materials including system analysis as supporter for aged people and as rehabilitation; Bioengineering and materials technology as applied to the decontamination against environmental problems; Biosensors, bioreactors, bioprocess instrumentation and control system; Application to food engineering; Standardization problems on biomaterials and related products; Assessment of reliability and safety of biomedical materials and man-machine systems; and Product liability of biomaterials and related products.
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Endoplasmic reticulum retention of KCNQ2 potassium channel mutants following temperature elevation

Authors: Yu, Fang | Xu, Jian | Xiao, Zheman | Peng, Biwen | He, Xiaohua

Article Type: Research Article

Abstract: Background: KCNQ2 plays a key role in the regulation of neuronal excitability. The R214W and Y284C mutants of KCNQ2 channels, which are associated with BFNC, can decrease channel function to cause neuronal hyperexcitability and promote seizures. Previous studies revealed that elevated temperature caused up-regulation of KCNQ2 expression. Objective: The present study sought to investigate the impact of temperature elevation on neuronal KCNQ2 ion channel mutants. Methods: Protein expression of wt KCNQ2 and the R214W, Y284C and truncated selective filter mutants at different temperatures was detected by live-cell confocal fluorescence microscopy and by Western blotting. Whole-cell patch … Show more

Keywords: KCNQ2, ion channels, temperature, febrile seizures, benign familial neonatal convulsions

DOI: 10.3233/BME-171647

Citation: Bio-Medical Materials and Engineering, vol. 28, no. s1, pp. S243-S253, 2017

Price: EUR 27.50

Advance of DNA and CCPs-based nanocarriers in drug delivery systems

Authors: Wu, Yu | Yao, Xihui | Chen, Yun | Li, Yinping | Tian, Weiqun

Article Type: Research Article

Abstract: Development of smart and functional polymeric carriers, which enable controlled or timed release of a bioactive material, thereby providing a better dosing pattern and minimizing side effects, becomes a new requirement in the field of drug delivery. In the recent few decades, a great many advancements of polymer synthetic methods have led to a new generation of bioactive polymers’ applications as drug controlled release carriers. In this review, we focus on the use of bioactive polymers for drug delivery system, with a particular in the utility of DNA-based nanocarriers and cell-penetrating peptides (CCPs)-based nanocarriers to provide precision control for drug … Show more

Keywords: DNA, cell-penetrating peptides, nanocarriers, drug delivery systems, targeting

DOI: 10.3233/BME-171648

Citation: Bio-Medical Materials and Engineering, vol. 28, no. s1, pp. S255-S261, 2017

Price: EUR 27.50
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