Advance of DNA and CCPs-based nanocarriers in drug delivery systems

Issue title: Selected papers from the 6th China–France International Symposium “Stem Cells and Regenerative Medicine” and the first meeting of the France–China International CNRS Network (GDRI) CeSMeR, Nancy, 10–13 July 2016

Guest editors: J.-F. Stoltz, J. Magdalou and D. Bensoussan

Article type: Research Article

Authors: Wu, Yu^a | Yao, Xihui^a | Chen, Yun^a | Li, Yinping^b | Tian, Weiqun^{a; *}

Affiliations: [a] Department of Biomedical Engineering, School of Basic Medical Sciences, Wuhan University, Wuhan 430071, China | [b] Department of Pathophysiology, School of Basic Medical Sciences, Wuhan University, Wuhan 430071, China

Correspondence: [*] Corresponding author: Weiqun Tian, Department of Biomedical Engineering, School of Basic Medical Sciences, Wuhan University, Wuhan 430071, China. Tel.: +86 27 68759509; Fax: +86 27 68759991; E-mail: tian_weiqun@whu.edu.cn.

Abstract: Development of smart and functional polymeric carriers, which enable controlled or timed release of a bioactive material, thereby providing a better dosing pattern and minimizing side effects, becomes a new requirement in the field of drug delivery. In the recent few decades, a great many advancements of polymer synthetic methods have led to a new generation of bioactive polymers’ applications as drug controlled release carriers. In this review, we focus on the use of bioactive polymers for drug delivery system, with a particular in the utility of DNA-based nanocarriers and cell-penetrating peptides (CCPs)-based nanocarriers to provide precision control for drug targeting or stimuli responsive systems.

Keywords: DNA, cell-penetrating peptides, nanocarriers, drug delivery systems, targeting

DOI: 10.3233/BME-171648

Journal: Bio-Medical Materials and Engineering, vol. 28, no. s1, pp. S255-S261, 2017