Acceleration of functional recovery from motor cortex ablation by two Ginkgo biloba extracts in rats

Article type: Research Article

Authors: Brailowsky, S. | Montiel, T. | Medina-Ceja, L.

Affiliations: Departamento de Neurociencias, Instituto de Fisiologia Celular, Universidad Nacional Autónoma de México (U.N.A.M.), Apdo. Postal 70-253, México 04510 D.F., Mexico

Note: [] Corresponding author. Tel.: +525 622 5761; Fax: +525 622 5607.

Abstract: We studied the effects of two extracts of Ginkgo biloba, with and without terpenes, on motor recovery from cortical hemiplegia. Both extracts of the reference product (EGb761-IPSEN) produced a dose-dependent acceleration of behavioral recovery and diminished ventricular dilation in lesion rats. These results indicate that the active substance(s) participating in the beneficial effect of EGb761 is (are) contained in the non-terpenic fraction of the extract.

Keywords: Hemiplegia, GABA, Beam test, Plasticity, Coordinated walking, Treatment, Brain injury

DOI: 10.3233/RNN-1995-8401

Journal: Restorative Neurology and Neuroscience, vol. 8, no. 4, pp. 163-167, 1995