Prism adaptation first among equals in alleviating left neglect: A review

Issue title: Plasticity in Spatial Neglect – Recovery and Rehabilitation

Article type: Research Article

Authors: Luauté, Jacques^{; ; ;} | Halligan, Peter | Rode, Gilles^{; ; ;} | Jacquin-Courtois, Sophie^{; ; ;} | Boisson, Dominique^{; ; ;}

Affiliations: Hospices Civils de Lyon, Hôpital Henry Gabrielle, Service de Rééducation Neurologique, Saint Genis Laval, F-69230, France | INSERM, U534, Espace et Action, Bron, F-69500, France | Université Claude Bernard Lyon 1, Faculté de Médecine, Lyon, F-69000, France | Institut Fédératif des Neurosciences de Lyon (IFNL), Hôpital Neurologique, Lyon, France | School of Psychology, Cardiff University, Cardiff, UK

Note: [] Corresponding author: Dr. Jacques Luauté, Hôpital Henry Gabrielle, 20, route de Vourles, 69230 Saint Genis-Laval, France. Fax: +33 4 78 86 50 30; E-mail: jacques.luaute@chu-lyon.fr

Abstract: Purpose: The current paper was designed to provide a critical overview on the different methods proposed for the rehabilitation of left spatial neglect. Methods: On the basis of a previous systematic review of the literature, we analyzed all articles available aiming at reducing left spatial neglect which included a long term functional assessment. Results: The aim of most early rehabilitation approaches, such as visuo-scanning training, was to re-orient visual scanning toward the neglected side. This review confirmed the utility of this method for rehabilitation purposes. More recent – theory driven – procedures, also based on a training approach, include limb activation, mental imagery training and video-feedback training. Although there is ground for optimism, the functional effectiveness of these methods still relies on few single-case studies. Newer methods have tried to stimulate automatic orientation of gaze or attention towards neglected space in a bottom-up fashion. Sensory stimulations can remove most of the classical signs of left neglect but their effects are short-lived. Such stimulations are not functionally relevant for rehabilitation except for trunk rotation or repeated neck muscle vibrations if they are associated with an extensive training program. A more promising intervention is prism adaptation given the growing evidence of relatively long-term functional gains from comparatively short term usage. Conclusion: Overall, there is now evidence for several clinically relevant long-term benefits in the case of visual scanning training, mental imagery training, video feedback training, neck muscle vibration and trunk rotation if associated with visual scanning training and prism adaptation. However, the amount of evidence is still limited to a small number of relevant published articles and it is mandatory to continue the research in this field. In this review, the possible routes for new rehabilitation procedures are discussed on the basis of the actual knowledge regarding the neuro-cognitive mechanisms underlying the therapeutic effect of prism adaptation.

Keywords: Left neglect, stroke, rehabilitation, prism adaptation, review

Journal: Restorative Neurology and Neuroscience, vol. 24, no. 4-6, pp. 409-418, 2006