Affiliations: Thrombosis, Haemostasis and Vascular Biology Unit, University Department of Medicine, The City Hospital, Dudley Road, Birmingham, B18 7QH, UK | Laboratoire Universitaire d’Hématologie, Faculté de Médecine, Université de Bordeaux II, 146 rue Leo Saignat, 33076 Bordeaux, France
Note: [] Corresponding author: Dr. Andrew D. Blann, Ph.D. FIBMS, Lecturer in Vascular Biology, Thrombosis, Haemostasis and Vascular Biology Unit, University Department of Medicine, The City Hospital, Dudley Road, Birmingham, B18 7QH, UK. Tel.: +44 121 507 5080; Fax: +44 121 554 4083.
Abstract: Damage to the endothelium is believed to be important in the development and progression of atherosclerosis. Consequently, vascular biologists are seeking good markers of endothelial cell function which hope to provide tools to dissect the role of these cells in disease. This review will examine a number of endothelial cell products (thrombomodulin, von Willebrand factor and soluble E‐selectin) and discuss their value as markers of vascular integrity.
Keywords: Atherosclerosis, endothelium, thrombomodulin, von Willebrand factor, soluble E‐selectin
