Vascular atherosclerotic disease: Behaviour of the red cell phospholipids and their relationships with the erythrocyte membrane fluidity. Preliminary report.

Issue title: Memorial Issue for Robin Fåhraeus (1888–1968)

Article type: Research Article

Authors: Caimi, Gregorio | Catania, Anna | Serra, Antonio | D’Asaro, Salvatrice | Lo Presti, Rosalia | Catalano, Concetta | Sarno, Antonio

Affiliations: Istituto di Clinica Medica e Malattie Cardiovascolari, Universitá di Palermo, Via del Vespro 129, 90127, Palermo

Note: [] Accepted by: Editor A.M. Ehrly

Abstract: In a group of subjects with vascular atherosclerotic disease (VAD), we evaluated the erythrocyte membrane individual phospholipids using the two-dimensional thin layer chromatography. From the obtained preliminary data, it is evident that no individual phospholipids discriminate normals from subjects with VAD. The study of the relationships between individual phospholipids and red cell membrane fluidity (evaluated using a fluorescence technique and marking the red cells with pyrene) has shown a slight positive correlation between this microrheological parameter and the phosphatidylethanolamine content only.

Keywords: Vascular atherosclerotic disease, Red cell phospholipids, Membrane microviscosity

DOI: 10.3233/CH-1988-8613

Journal: Clinical Hemorheology and Microcirculation, vol. 8, no. 6, pp. 925-928, 1988