Erythrocyte deformability (ED) and oxidative sensitivity (OS) in haemodialysis patients (HD)

Issue title: The Fifth European Conference on Clinical Hemorheology. Part I

Article type: Research Article

Authors: Zachée, P.^a | Emonds, M.P.^a | Goossens, W.^a | Daelemans, R.^b | Lins, R.L.^b | Boogaerts, M.A.^a

Affiliations: [a] University of Leuven, Belgium | [b] A.Z.Stuivenberg, Antwerp, Belgium

Note: [] Accepted by: Guest Editor M. Duchesne-Gueguen

Abstract: Oxidative sensitivity, measured by a modified ascorbate cyanide test, GSH and 51 Cr-RBC cytotoxicity, was abnormal before the haemodialysis. This increases after 30 min. dialysis, just behind the leukocytes drop. Biocompatible dialysis membranes do attenuate this phenomenon. All are indicative of RBC scavenger function against toxic oxygen radical production in dialysis patients. Despite this abnormality, erythrocyte deformability was completely normal.

Keywords: Oxidative sensitivity, toxic oxygen radical, haemodialysis, erythrocyte deformability, scavenger

DOI: 10.3233/CH-1988-83-422

Journal: Clinical Hemorheology and Microcirculation, vol. 8, no. 3-4, pp. 439-443, 1988