Rheology of hemodialysed patients: Erythrocytic populations study. Effect of a low molecular weight heparin (K 2165)

Issue title: The Fifth European Conference on Clinical Hemorheology. Part I

Article type: Research Article

Authors: N’Guyen, P.^a | Adjizian, J.C.^a | Toupance, O.^b | Jolly, D.^a | Brissart, A.^a | Petitfrere, E.^a

Affiliations: [a] Laboratoire central d’Hématologie (Pr G. Potron), Centre Hospitalier Universitaire, rue Alexis Carrel, 51092 Reims, Cédex | [b] Unité de Néphrologie (Pr J. Chanard), Centre Hospitalier Universitaire, rue Alexis Carrel, 51092 Reims, Cédex

Note: [] Accepted by: Guest Editor M. Duchesne-Gueguen

Abstract: The purpose of our study is to evaluate the influence of the type of anticoagulation (standard heparin versus LMWH K 2165 KABI) as well as the type of membrane used for hemodialysis on hemostatic and hemorheological parameters. We have tested 26 hemodialysed patients. While red blood cell deformability was markedly impaired in these patients, we have not find any effect of hemodialysis. Increase of plasmatic and whole blood viscosity were mainly due to hemoconcentration. No influence of the type of membrane was found. Low molecular weight heparin K 2165 could be used safely. The importance of hemostatic parameters and their rheological consequences is stressed.

Keywords: hemodialysis, low molecular weight heparin, erythrocytic populations, rheology, hemostasis

DOI: 10.3233/CH-1988-83-419

Journal: Clinical Hemorheology and Microcirculation, vol. 8, no. 3-4, pp. 415-423, 1988