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Article type: Research Article
Authors: Liao, Fu-long | Li, Wen | Huang, Shen
Affiliations: Department of Pharmacology, Institute of Chinese Materia Medica, China Academy of Traditional Chinese Medicine, Beijing, China
Note: [] Accepted by: Editor H. Hartert
Abstract: HAAKE Rotovisco RV100/CV100 was employed to investigate coagulation of whole blood, platelet rich plasma (PRP) and plasma. Samples were anticoagulated with sodium citrate. Clotting was initiated by adding CaCl2 Shear stress versus time at shear rate 0.3 s−1 at 37°C was recorded. Two parameters were established: (1) Recalcification time tr; and (2) viscosity increasing rate dη/dt. The parameters appeared to be meaningful to the clotting behaviour of blood, PRP and plasma. Several antithrombotics were tested by the method. Warfarin prolonged tr with a dramatic suppression of dη/dt (P<0.001). Aspirin decreased dη/dt (P<0.001) without significant influence on tr. Heparin showed dose-response correlations for both the parameters. The unconventional test of clotting by rotational viscometer may have its potential in clinical practice of hemorheology.
Keywords: Hemorheology, Blood viscosity, Clotting, Antithrombotics, Aspirin, Heparin
DOI: 10.3233/CH-1987-7502
Journal: Clinical Hemorheology and Microcirculation, vol. 7, no. 5, pp. 671-677, 1987
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