Influence of urokinase on the flow properties of blood

Article type: Research Article

Authors: Ehrly, A.M. | Fuchs, H.

Affiliations: Division of Angiology, Department of Internal Medicine, J.-W.-Goethe-University Medical School, 6000 Frankfurt 70, Federal Republic of Germany

Note: [] Accepted by: Editor H. Hartert

Abstract: In healthy volunteers and patients with severe chronic occlusive arterial diseases, Urokinase was given intravenously. There is a dose dependend decrease in fibrinogen concentration, whole blood viscosity, plasma viscosity and red cell aggregability whereas red cell filtrability remains unchanged. This influence of Urokinase on the flow properties of blood could be responsible for some clinical improvements in patients with vascular disorders even when a thrombolytic effect is not yet detectable. Long term systemic low dose Urokinase treatment could be a promising approach in severe stages of ischemic diseases.

Keywords: Low dose Urokinase, blood viscosity, erythrocyte aggregation

DOI: 10.3233/CH-1987-7501

Journal: Clinical Hemorheology and Microcirculation, vol. 7, no. 5, pp. 665-669, 1987