Short‐term effects of an intensive lifestyle modification program on lipid peroxidation and antioxidant systems in patients with coronary artery disease
Affiliations: Department of Biochemistry, King Chulalongkorn Memorial Hospital, Bangkok, Thailand | Department of Medicine, King Chulalongkorn Memorial Hospital, Bangkok, Thailand | Department of Physiology, King Chulalongkorn Memorial Hospital, Bangkok, Thailand | Department of Psychiatric Nursing, King Chulalongkorn Memorial Hospital, Bangkok, Thailand | Department of Nursing, Ramathibodi Hospital, Bangkok, Thailand
Abstract: The purpose of this study was to compare the short‐term effects of an intensive lifestyle modification (ILM) program on lipid peroxidation and antioxidant systems in patients with coronary artery disease (CAD). Twenty‐two patients in the control group continued to receive their conventional treatment with lipid‐lowering drugs, whereas 22 patients in the experimental group were assigned to intensive lifestyle modification (ILM) without taking any lipid‐lowering agent. The ILM program comprised dietary advice on low‐fat diets, high antioxidants and high fiber intakes, yoga exercise, stress management and smoking cessation. After 4 months of intervention, patients in the experimental group revealed a statistically significant increase in plasma total antioxidants, plasma vitamin E and erythrocyte glutathione (GSH) compared to patients in the control group. There was no significant change in plasma malondialdehyde (MDA), a circulating product of lipid peroxidation, in either group. We concluded that the ILM program increased circulating antioxidants and reduced oxidative stress in patients with CAD.
