Deformability and enzymes activities of red blood cells in hemodialysed and peritoneal dialysed patients with chronic renal disease

Article type: Research Article

Authors: Nowak‐Piszczek, Ewa^; | Wyrwicz, Grażyna | Dąbrowski, Zbigniew^; | Smoleński, Olgierd | Spodaryk, Krzysztof

Affiliations: Department of Hematology and Toxicology, Institute of Zoology, Jagiellonian University, Ingardena 6, 30‐060 Cracow, Poland | Department of Biochemistry, Agricultural University of Warsaw, Rakowiecka 26/30, 02‐528 Warsaw, Poland | Department of Nephrology and Dialysis, Rydygier Hospital, Osiedle Złotej Jesieni 1, 31‐826 Cracow, Poland | Academy of Physical Education, Institute of Rehabilitation, Al. Jana Pawła II 88, 31‐571 Cracow, Poland

Note: [] Corresponding author: Z. Dąbrowski. Tel.: +48 12 6336377, ext. 2453; Fax: +48 12 6340785; E‐mail: dabro@zuk.iz. uj.edu.pl.

Abstract: These studies were focused on the influence of two treatment methods of patients with chronic renal disease on RBC deformability. In peritoneal dialysed‐patients (PD) erythrocytes exhibited a decrease in their deformability as compared to control subjects whereas this parameter in RBC deriving from hemodialysed patients (HD) was not altered. The alleviating effect of plasma components on deformability of erythrocytes was confirmed after the isolation of a pure faction of these cells as the parameter became worse. The activity of studied enzymes: acetylcholinesterase (Ache), dehydrogenase glucose‐6‐phosphate (G‐6‐PD) and glutathione reductase (GR) maintained their physiological values in both dialysis groups.

Keywords: Hemodialysis, peritoneal dialysis, erythrocyte deformability, acetylcholinesterase, dehydrogenase glucose‐6‐phosphate, glutathione reductase

Journal: Clinical Hemorheology and Microcirculation, vol. 28, no. 4, pp. 251-257, 2003