Affiliations: Hemorheology and Thrombosis Unit, Department of Clinical Pathology, La Fe University Hospital, Valencia, Spain | Molecular Biology Unit, Department of Clinical Pathology, La Fe University Hospital, Valencia, Spain | Hematology Service, La Fe University Hospital, Valencia, Spain
Note: [] Corresponding author: Amparo Vayá, MD, PhD, Hemorheology and Thrombosis Unit, Department of Clinical Pathology, La Fe University Hospital, Avda. Cmpanar 21, Valencia 46009, Spain. Tel.: +34 963 86 27 14; Fax: +34 96 197 30 89; E‐mail: vaya_amp@gva.es.
Abstract: In major and intermediate thalassemia a decrease in erythrocyte deformability and increased erythrocyte aggregability has been described, but few studies have dealt with the question of rheological red blood cell behaviour in minor β and δβ thalassemia carriers, mostly in δβ, because it is a less common entity. To ascertain whether there are differences in red blood cell behaviour between minor thalassemia and controls and between both types of thalassemia trait β and δβ, we determined erythrocyte deformability and aggregability in 30 β and 30 δβ trait carriers diagnosed both with conventional methods and globin gene analysis, and in 40 age‐ and sex‐matched controls. Erythrocyte deformability determined by means of the Rheodyn SSD showed a statistically significant lower Elongation Index (EI) at all the shear stresses tested in both thalassemic groups compared with controls (p<0.001). Minor β thalassemia carriers showed lower EI than δβ carriers (p<0.001). Erythrocyte aggregability measured with the Myrenne aggregometer was significantly lower in both thalassemic groups than in controls (p<0.001), although no significant differences could be observed between both thalassemic groups. The rheological alterations found in thalassemia carriers are in part due to microcytosis, hypochromia and the morphological changes that characterize this kind of anaemia. The less altered deformability found in δβ carriers, is in agreement with the fact that it deals with a more benign trait.
