Affiliations: Department of Drug Safety Evaluation, Wyeth Institute of Medical Research, Huntercombe Lane South, Taplow, Maidenhead, SL6 OPH, U.K.
Note: [] Accepted by: Editor J.A. Dormandy
Abstract: Three vasoactive compounds (oxpentifylline, prazosin and indoramin) were given to beagle dogs in three separate studies. Oxpentifylline produced decreases in whole blood viscosity and in the viscosity of blood corrected to a standard haemoglobin concentration of 16.0g/dl. These effects, however, were not consistent. Prazosin produced a sustained decrease in whole blood viscosity related to a decreased red cell population and an improvement in blood rheology at the cellular level (red cell deformability and red cell aggregation). Indoramin produced a decrease in whole blood viscosity related to a decreased red cell population, this effect was not sustained in the beagle dog.
