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Article type: Research Article
Authors: Small, M. | Tweddel, A.C. | Burns, P. | Rankin, A.C. | Lowe, G.D.O. | Forbes, C.D.
Affiliations: University Departments of Medicine and Cardiology, Royal Infirmary, Glasgow G4 OSF
Note: [] Accepted by: Editor S. Chien
Abstract: The effects of two beta-adrenoceptor antagonist drugs, propranolol and carteolol, on blood viscosity and its determinants were assessed in a double-blind, placebo-controlled study of 9 normal males, both at rest and following maximal exercise. Blood viscosity increased significantly at both high and low shear rates following exercise, and this was unaltered by effective beta-blockade. The increase in viscosity was associated with significant increases in haematocrit, plasma viscosity and fibrinogen level. Propranolol increased resting blood viscosity (corrected for haematocrit) at the high shear rate, a potential adverse effect not observed with carteolol. The increase in blood viscosity on exercise might reduce blood flow in subjects with occlusive arterial disease, and hence may have clinical implications.
Keywords: exercise, blood rheology, beta-adrenoceptor antagonism
DOI: 10.3233/CH-1985-5401
Journal: Clinical Hemorheology and Microcirculation, vol. 5, no. 4, pp. 281-289, 1985
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