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Article type: Research Article
Authors: Ohlmann, P.; | Jung, F. | Mrowietz, Ch. | Alt, T. | Alt, S. | Schmidt, W.
Affiliations: Department of Obstetrics and Gynecology, University of Saarland, Homburg/Saar, Germany | Dresden Institute of Cardiovascular Research, Dresden, Germany
Note: [] Corresponding author: Dr. med. Paul Ohlmann, Department of Obstetrics and Gynecology, Marienkrankenhaus Papenburg‐Aschendorf, Hauptkanal 75, 26871 Papenburg, Germany. Fax: +49 4961 931379; E‐mail: Info@Marienkrankenhaus‐Papenburg.de.
Abstract: During pregnancy the cardiovascular system undergoes several changes so as to adapt the maternal organism to the strains of pregnancy. These adaptations can assume a pathological development in persons with a previous history of cardiovascular problems. On the other hand the absence of these adaptations may lead to a pathological course of pregnancy. Pregnancy induced hypertension (PIH) may be such a pathological development due to maladaptation. The causes are for the most part unknown. For some time it has been assumed that it is due to microcirculatory disorders. Using periungual capillary microscopy the present study prospectively investigated the changes in peripheral microcirculation during pregnancy focussing on pregnancy induced hypertension. Sixty‐seven women with a normal course of pregnancy and 28 women with pregnancy induced hypertension were evaluated. Throughout the prospective study 3 examinations were performed during pregnancy and one during childbed. The women who developed a PIH were registered during the third trimester. Erythrocyte velocity at rest and vascular reagibility of capillaries following a 3 minute ischaemia were evaluated. In the course of pregnancy a significant increase of approximately 30% in erythrocyte velocity could be observed. Interpolation to obtain the best strait line result demonstrates that it is a continuous increase. Erythrocyte velocity returns to normal in the course of 14 weeks post partum. Due to a physiological vasodilatation during pregnancy, vascular reaction to ischaemic stress significantly decreases. During childbed these changes return to normal. Examinations on women with pregnancy induced hypertension not only showed a significant reduction of microcirculation under resting conditions but also a different pattern of reaction to ischaemic stress. Erythrocyte velocity under resting conditions lies 36% below normal values. Furthermore the distinctly shortened hyperaemic period indicates a hightened sensitivity to vasoconstrictive substances in women with PIH. While taking into account the clinical data a positive correlation with the severity of the illness was able to be established.
Journal: Clinical Hemorheology and Microcirculation, vol. 24, no. 3, pp. 183-191, 2001
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