Interactions between intravascular coagulation and tissue perfusion

Issue title: Proceedings of Fifth International Congress of Biorheology. Baden-Baden, F.R. Germany, 20–24 August 1983. Symposium on Hemorheological Disorders in Cardiovascular Diseases

Guest editors: Alfred L. Copley and Siegfried Witte

Article type: Research Article

Authors: Neuhof, H. | Lasch, H.G.

Affiliations: Department of Internal Medicine, Division of Clinical Pathophysiology and Experimental Medicine, Justus Liebig-University, 6300 Giessen, F.R.G.

Abstract: During intravascular coagulation and fibrinolysis, intermediates and degradation products with potent effects on vascular tone and permeability are generated. They act predominantly in the pulmonary circulation and cause vasoconstriction and vascular leakage. Their effects are mediated partially by platelets and neutrophils and partially by direct stimulation of the pulmonary arachidonic acid metabolism, resulting in the generation of vasoactive prostanoids. Thus the activation of the coagulation system may result in changes of tissue perfusion even in the absence of fibrin clots and platelet aggregates.

Keywords: fibrinopeptides, fibrin monomers, fibrin(ogen) degradation products, arachidonic acid metabolites, pulmonary circulation, vascular effects

DOI: 10.3233/CH-1984-4103

Journal: Clinical Hemorheology and Microcirculation, vol. 4, no. 1, pp. 5-13, 1984