Affiliations: Department of Medical Physics, Beijing Medical University, Beijing 100083, P.R. China | Department of Radiology of the Third Hospital of Beijing Medical University, Beijing 100083, P.R. China | Analysis Center, Beijing Medical University, Beijing 100083, P.R. China | Department of Mechanics and Engineering Sciences, Peking University, Beijing 100871, P.R. China
Note: [] Corresponding author: Prof. Zongyao Wen, Department of Biophysics, Beijing Medical University, Beijing 100083, Xue Yuan Road 38, Haidian District, Beijing, P.R. China. Tel.: +8610 62092419; Fax: +8610 62015582; E‐mail: rheol@mail.bjmu.edu.cn.
Abstract: To evaluate the change of hemorheological indexes for patients with Alzheimer's disease (AD) at the early stages and to discuss effects of these changes on AD, high shear value of whole blood viscosity (ηbh), reduced high shear value of whole blood viscosity (rηbh), low shear value of whole blood viscosity (ηbl), reduced low shear, value of whole blood viscosity (rηbl), KT value of whole blood viscosity, hematocrit (HCT) and blood plasma viscosity (ηP) were measured in 31 patients with probable AD at the early stages and 33 age‐matched healthy subjects. There were significant differences of all hemorheological indexes between AD group and control group except HCT. Step discriminant analysis revealed 81.25% of overall group‐classified accuracy in a hemorheological discriminant function consisting of ηbl, rηbl, rηbh and HCT. Significant difference of hemorheological indexes existed between AD and age‐matched healthy control subjects. The results showed that measurement of hemorheological indexes could be used as one of reference standards of diagnosis in AD.
