Prognostic significance of serum inflammatory markers in patients with acute ischemic stroke undergoing revascularization therapy

Article type: Research Article

Authors: Tang, Ding-Zhong^a | Wang, Wei-Wei^b | Chen, Xin-Xin^a | Yin, Song-He^a | Zhang, Lei^a | Liang, Xue-Lin^a | Luo, Guo-Jun^{a; *} | Yu, Chun-Li^{c; *}

Affiliations: [a] Department of Neurology Medical, Jinshan Branch of Shanghai Sixth People’s Hospital, Shanghai, China | [b] Department of Hospital Infection Management, Jinshan Branch of Shanghai Sixth People’s Hospital, Shanghai, China | [c] Department of Renal Medical, Jinshan Branch of Shanghai Sixth People’s Hospital, Shanghai, China

Correspondence: [*] Corresponding authors: Chun-Li Yu, Department of Renal Medical, Jinshan Branch of Shanghai Sixth People’s Hospital, No. 147 of Jiankang Road, Zhujing Town, Jinshan District, Shanghai 201599, China. Tel.: +86 18721939029; E-mail: 18721939029@163.com and Guo-Jun Luo, Department of Neurology Medical, Jinshan Branch of Shanghai Sixth People’s Hospital, No. 147 of Jiankang Road, Zhujing Town, Jinshan District, Shanghai 201599, China. Tel.: +86 13641676089; E-mail: lgj13641476089@163.com.

Abstract: OBJECTIVE:This study aimed to evaluate the prognostic significance of serum inflammatory factor levels in patients with acute ischemic stroke undergoing revascularization therapy. METHODS:The study included 94 patients with acute ischemic stroke who underwent revascularization therapy at our hospital. The primary outcome was the modified Rankin scale (mRS) score assessed three months post-treatment. Patients were categorized into two groups: those with a poor prognosis (mRS score > 2) and those with a good prognosis (mRS score≤2). The patients were divided into two groups based on the type of revascularization treatment received: thrombus extraction or intravenous thrombolysis. Logistic regression analysis was used to identify independent risk factors associated with the prognosis of patients treated with recanalization for acute ischemic stroke. RESULTS:Among the 94 patients, 59 had a good prognosis, and 35 had a poor prognosis. At admission, the patients in the good prognosis group exhibited lower NIHSS scores, shorter hospital stays, fewer previous cardiac events, lower LDL levels, fasting glucose, IL-6, and TNF-a compared to those in the poor prognosis group (all P < 0.05). Logistic regression analysis identified TNF-a (odd ratio (OD), 1.623; 95% confidence interval (CI), 1.282–1.933; P = 0.035) and IL-6 (OD, 1.055; 95% CI, 1.024–1.088, P = 0.023) as independent risk factors for poor prognosis in patients after revascularization. Additionally, pre-hospital NIHSS scores, IL-6, and TNF-a levels were significantly lower in the good prognosis group compared to the poor prognosis group, with these differences being statistically significant. CONCLUSION:IL-6 and TNF-α may serve as prognostic markers for outcomes following revascularization therapy in patients with acute ischemic stroke, including those receiving intravenous thrombolysis.

Keywords: IL-6, prognosis, revascularization therapy, risk factors, TNF-a

DOI: 10.3233/CH-242435

Journal: Clinical Hemorheology and Microcirculation, vol. 88, no. 4, pp. 513-522, 2024