Affiliations: [a] Department of Exercise Physiology, Faculty of Sport Sciences, Razi University, Kermanshah, Iran
| [b] Faculty of Physical Education and Sport Science, Shahid Rajaee Teacher Training University, Tehran, Iran
| [c] Department of Exercise Physiology, Faculty of Sport Sciences, Hakim Sabzevari University, Sabzevar, Iran
| [d] Department of Geriatrics and Orthopedics, Università Cattolica del Sacro Cuore, Rome, Italy
| [e] Fondazione Policlinico Universitario “A. Gemelli” IRCCS, Rome, Italy
| [f] Faculty of Health Sciences Brandenburg, Brandenburg University of Technology Cottbus-Senftenberg, Senftenberg, Germany
| [g] Department of Chemistry, Columbia University, NewYork, NY, USA
| [h] Department of Biological Sciences, Columbia University, New York, NY, USA
Correspondence:
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Corresponding author: Negin Kordi, Department of Exercise Physiology, Faculty of Sport Sciences, Razi University, Kermanshah, Iran. E-mail: n.kordi@razi.ac.ir.
Abstract: Ferroptosis is a form of programmed cell death that plays a significant role in causing several diseases such as heart attack and heart failure, through alterations in fat, amino acid, and iron metabolism. Comprehending the regulatory mechanisms of ferroptosis signaling is critical because it has a considerable effect on the elderly’s mortality. Conversely, age-related changes in substrate metabolism and metabolite levels are recognized to give rise to obesity. Furthermore, research has proposed that aging and obesity-related changes in substrate metabolism may aggravate ferroptosis. The suppression of ferroptosis holds potential as a successful therapeutic approach for managing different diseases, including sarcopenia, cardiovascular diseases, and central nervous system diseases. However, the pathologic and biological mechanisms behind the function of ferroptosis are not fully comprehended yet. Physical activity could affect lipid, amino acid, and iron metabolism to modulate ferroptosis. The aim of this study is to showcase the current understanding of the molecular mechanisms leading to ferroptosis and discuss the role of aging and physical activity in this phenomenon.
