Affiliations: [a] Division of Interventional Ultrasound, Department of Medical Ultrasonics, Institute of Diagnostic and Interventional Ultrasound, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China
| [b] Division of Interventional Ultrasound, Department of Medical Ultrasonics, Foshan First Municipal People’s Hospital (The Affiliated Foshan Hospital of Sun Yat-sen University), Foshan, Guangdong, China
| [c] Medical imaging System Division General manager Shenzhen Mindray Bio-medical Electronics. LTD, Shenzhen, China
Correspondence:
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Corresponding author: Guangliang Huang, Institute of Diagnostic and Interventional Ultrasound, Sun Yat-Sen University; Department of Medical Ultrasonics, The First Affiliated Hospital of Sun Yat-sen University, 58 Zhong Shan Road 2, Guangzhou-510080, China. Tel./Fax: +86 020 87765183; E-mail: huanggl9@mail.sysu.edu.cn.
Note: [1] These authors contributed to this work equally.
Abstract: BACKGROUND:Registration of three-dimensional contrast-enhanced ultrasound fusion imaging (3DCEUS-FI) is time-consuming to obtain high success rate. OBJECTIVE:To investigate the influence factors on registration success rate of 3DCEUS-FI. METHODS:Water tank phantoms were made to obtain mimicked pre- and post- radiofrequency ablation three-dimensional contrast-enhanced ultrasound (3DCEUS) and CT images. Orthogonal trials were designed according to factors including size, depth, enhancement level of mimicked tumor, diameter and number of mimicked adjacent vessels. Mimicked pre- and post-RFA 3DCEUS images of 72 trials were fused to assess ablative margin (AM) by two radiologists. With CT images as standard, 3DCEUS-FI accuracy was considered as the consistency of AM evaluation. The inter-observer agreement and the influence factors on registration success rates were analyzed. RESULTS:The intraclass correlation coefficient (ICC) for the consistency of AM evaluation between CT and 3DCEUS-FI in x-axis, y-axis or z-axis was 0.840∼0.948 (P < 0.001). The ICC for inter-observer agreement was 0.840∼0.948 (P < 0.001). The success rates of registration within mimicked vessels with diameter of 2 mm were significantly lower than those with diameter of 3 mm and 4 mm. CONCLUSIONS:The mimicked AM measured by 3DCEUS-FI had high accuracy and inter-observer agreement. Diameter of the mimicked adjacent vessels was significantly related to success rate of registration.
