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Issue title: 40th Conference of the German Society for Clinical Microcirculation and Hemorheology, 5-6 November 2021, Senftenberg, Germany
Guest editors: J.-H. Küpper, A. Krüger-Genge and F. Jung
Article type: Research Article
Authors: Senk, Karina; * | Wilcke, Julianec | Haimerl, Michaela | Verloh, Niklasa | Rio Bartulos, Carolinab | Bäumler, Wolfa | Stroszczynski, Christiana | Wiggermann, Philippb
Affiliations: [a] Institut für Röntgendiagnostik, Universtitätsklinikum Regensburg, Regensburg, Germany | [b] Institut für Röntgendiagnostik und Nuklearmedizin, Städtisches Klinikum Braunschweig gGmbH, Braunschweig, Germany | [c] Institut für Psychologie, Universität Kassel, Kassel, Germany
Correspondence: [*] Correspondence to: Karin Senk, Institut für Röntgendiagnostik, Universtitätsklinikum Regensburg, Regensburg,Germany. Tel.: +49 941 944 7410; E-mail: Karin.Senk@klinik.uni-regensburg.de.
Abstract: BACKGROUND AND OBJECTIVE:Liver function is one of the most important parameters for the outcome of transarterial chemoembolization (TACE). The liver maximum capacity (LiMAx) test is a bedside test that provides a real-time option for liver function testing. The objective of this pilot study was to investigate the suitability of the LiMAX test for predicting the TACE outcome. METHODS:20 patients with intermediate-stage hepatocellular carcinoma (HCC) received a LiMAx test 24 h pre and post TACE. In addition, laboratory values were collected to determine liver function and model for endstage liver disease (MELD) scores. The success of TACE was assessed 6 weeks post intervention by morphological imaging tests using modified response evaluation criteria in solid tumors (mRECIST). RESULTS:Patients with an objective response (OR = CR + PR) according to mRECIST post TACE had significantly higher values in the pre-interventional LiMAx test than patients with a non-OR (PD or SD) post TACE (r(14) = 0.62, p = 0.01). Higher pre-interventional LiMAx values therefore indicate OR. Patients with a disease control (DC = CR + PR + SD) according to mRECIST post TACE had significantly higher values in the pre-interventional LiMAx test than patients with a non-DC (PD) post TACE (r(14) = 0.65, p = 0.01). Higher pre-interventional LiMAx values therefore indicate DC. The point biserial correlations of LiMAx values pre and post TACE with the outcome OR or DC were descriptively stronger than those of MELD with OR or DC. This suggests that the LiMAx test correlates better with the treatment response than the MELD score. CONCLUSIONS:For the first time, we were able to show in our study that patients who are scheduled for TACE could benefit from a LiMAx test to be able to estimate the benefit of TACE. The higher the pre-interventional LiMAx values, the higher the benefit of TACE. On the other hand, laboratory parameters summarized in the form of the MELD score had significantly less descriptive correlation with the TACE outcome.
Keywords: TACE, LiMAx, HCC, MRECIST, methacetin breath test, liver function, outcome
DOI: 10.3233/CH-219118
Journal: Clinical Hemorheology and Microcirculation, vol. 79, no. 1, pp. 73-80, 2021
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