The clinical significance of disturbances of microcirculation in the pathogenesis of arteriosclerosis

Issue title: Microcirculation, Interstitium, Lymph, Pathophysiology and Disease. Proceedings of the International Symposium, Villa La Principessa, Lucca, Italy, June 19–20, 1981

Guest editors: Siegfried Witte

Article type: Research Article

Authors: Hauss, W.H.

Affiliations: Institut für Arterioskleroseforschung an der Universität Münster, F.R. Germany

Abstract: The microcirculation takes place in 2 histological areas, in an intravascular and in an intramural part. Both parts are produced by vessel wall cells which are mesenchymal cells. A larger number of heterogenous stimuli and injuries, especially the so-called risk factors, directly and regularly induce a reactive alteration of the mesenchymal metabolism (the “non-specific mesenchymal reaction”). Two types of the intramural part are serving for the microcirculation: a) the intramural part in the vessel wall and b) the intramural part in the capillary wall. The histological consequences of the reactive pathological metabolism in the intramural part are described particularly with regard to the pathogenesis of arteriosclerosis of circulatory disturbances.

Keywords: Arteriosclerosis, arterial wall, myocard, hypertension, diabetes

DOI: 10.3233/CH-1982-25-626

Journal: Clinical Hemorheology and Microcirculation, vol. 2, no. 5-6, pp. 705-719, 1982