N-terminal pro-brain natriuretic peptide used for screening hemodynamically significant patent ductus arteriosus in very low birth weight infants: How and when?

Article type: Research Article

Authors: Liu, Ying^{a; *} | Huang, Zhen-Li^b | Gong, Lin^b | Zhang, Zhen^a | Zhang, Shuang-Chuan^a | Zhou, Yu-Xin^a

Affiliations: [a] Department of Neonatology, Peking University Shenzhen Hospital, ShenZhen, Guangdong, China | [b] Department of Ultrasonic Diagnosis, Peking University Shenzhen Hospital, ShenZhen, Guangdong, China

Correspondence: [*] Corresponding author: Ying Liu, Department of Neonatology, Peking University Shenzhen Hospital, ShenZhen, Guangdong, 518000, China. E-mail: liuying981@163.com.

Abstract: Background:N-terminal pro-B-type natriuretic peptide (NTproBNP) appears to be a useful tool for diagnosing hemodynamically significant patent ductus arteriosus (hsPDA) in preterm infants. However, a consensus for its application has not been reached. Objective:The present study aims to evaluate the role of NTproBNP in predicting hsPDA in preterm infants, and explore the optimal cutoff value and testing-time. Methods:A prospective blind study of 120 preterm infants with birth weights of < 1,500 g was conducted at the NICU of Peking University Shenzhen Hospital. Blood samples were successively collected on the first three days after birth for NTproBNP analysis. Echocardiographies were performed on day three of life to confirm the status of the ductus arteriosus. A receiver operating characteristic curve (ROC) analysis was performed to determine the ability of NTproBNP to recognize hsPDA. Results:NTproBNP was significantly higher in infants with hsPDA, than in infants in the control group, on both day two (P < 0.001) and day three (P < 0.001). On day two, a NTproBNP cutoff value of 3,689.0 pmol/L offered an optimal predictive value for hsPDA, while on day three, the optimal cut-off value for hsPDA was 2,331.5 pmol/L. The investigators proposes day three of life (48–72 hours) as the optimal testing time. Conclusion:The NTproBNP biomarker during the early neonatal period can be a useful tool for screening and assessing hsPDA in premature infants, especially on day three of life.

Keywords: HsPDA, NTproBNP, preterm infants, very low birth weight infants

DOI: 10.3233/CH-190803

Journal: Clinical Hemorheology and Microcirculation, vol. 75, no. 3, pp. 335-347, 2020