Coronary microvascular disease and clinical prognosis in deferred lesions: The index of microcirculatory resistance

Issue title: Selected Papers of the Joint Conference of the ESCHM-ISCH-ISB-2018, 2-6 July, 2018, Krakow, Poland

Guest editors: F. Jung and M. Fornal

Article type: Research Article

Authors: Chung, Ju-Hyun^a | Lee, Kyung Eun^b | Park, Jai-Wun^c | Shin, Eun-Seok^{a; *}

Affiliations: [a] Division of Cardiology, Ulsan Medical Center, Ulsan Hospital, Ulsan, Republic of Korea | [b] Department of Mechanical and Biomedical Engineering, Kangwon National University, Chuncheon, Republic of Korea | [c] Division of Cardiology, Dietrich Bonhoeffer Hospital, Academic Teaching Hospital of University of Greifswald, Germany

Correspondence: [*] Corresponding author: Eun-Seok Shin, MD, PhD Division of Cardiology, Department of Internal Medicine, Ulsan Medical Center, Ulsan Hospital, 13, Wolpyeong-ro 171beon-gil, Nam-gu, Ulsan, 44686, Republic of Korea. Tel.: +82 52 259 5020; Fax: +82 52 259 5117; E-mail: sesim1989@gmail.com.

Abstract: While fractional flow reserve (FFR) is a good diagnostic index to assess the myocardial ischemia, coronary flow reserve (CFR) and the index of microcirculatory resistance (IMR) can be used to address microvascular status without any significant epicardial disease. The independent predictors for FFR and IMR are totally different and acts differently on the macro- and micro-vascular dysfunction. In high FFR patients, low CFR and high IMR which indicates the presence of overt microvascular disease demonstrated poor prognosis. Thus, comprehensive physiological assessments using FFR, CFR and IMR could improve the ability to discriminate patients at high risk of future events.

Keywords: Microvascular dysfunction, fractional flow reserve, coronary flow reserve, index of microcirculatory resistance

DOI: 10.3233/CH-189403

Journal: Clinical Hemorheology and Microcirculation, vol. 71, no. 2, pp. 137-140, 2019