Issue title: Selected articles of the 14th International Congress of Biorheology and the 7th International Conference of Clinical Hemorheology, July 4–7, 2012, Istanbul, Turkey
Article type: Research Article
Authors: Lee, Sang-Rok | Jung, Jin-Mu | Jung, Lae-Young | Lee, Ju-Hyung | Lee, Sun-Hwa | Rhee, Kyoung-Suk | Chae, Jei Keon | Kim, Won Ho | Ko, Jae Ki | Lee, Dong-Hwan | Rosenson, Robert S.
Affiliations: Division of Cardiology, Chonbuk National University Hospital, Jeonju, South Korea | Department of Mechanical Engineering and Mechanics, Drexel University, Philadelphia, PA, USA | Department of Preventive Medicine, Chonbuk National University Hospital, Jeonju, South Korea | Department of Mechanical Engineering and Mechanics, Chonbuk National University, Jeonju, South Korea | Mount Sinai Heart, Mount Sinai School of Medicine, New York, NY, USA
Note: [] Corresponding author: Sang-Rok Lee, MD, PhD, Research Institute of Clinical Medicine, Chonbuk National University–Biomedical Research Institute of Chonbuk National University Hospital, 42 Wonjam-5-gil, Deokjin-gu, Jeonju, Jeonbuk, 561-712, South Korea. Tel.: +82 63 250 2418; Fax: +82 63 250 1680; E-mail: medorche@jbnu.ac.kr Sang-Rok Lee and Jin-Mu Jung contributed equally to this article.
Note: [] Sang-Rok Lee and Jin-Mu Jung contributed equally to this article.
Abstract: OBJECTIVES: As most clinical studies measure whole blood viscosity (WBV) from peripheral samples, potential differences in WBV obtained from the coronary arteries are often ignored. This study investigated differences in WBV measured from coronary artery specimens in patients with and without acute coronary syndrome (ACS). METHODS AND RESULTS: Consecutive patients with chest pain who underwent diagnostic coronary angiography were divided into two groups [non-ACS (n = 16), ACS (n = 22)]. The ACS group consisted of unstable angina (n = 13) and acute myocardial infarction (n = 9) patients. Two blood samples were obtained from each patient at the both coronary artery ostia prior to coronary angiography. Low-shear and high-shear blood viscosities (BVs) were measured at shear rates of 1 and 300 s−1, respectively, by a scanning capillary tube viscometer (Bio-Visco Inc., SouthKorea). Both low-shear and high-shear BVs obtained from peripheral, left and right coronary arteries were not different in both groups. Mean coronary low-shear WBV values obtained in ACS group were 29.2% higher than those in non-ACS group (295.3 ± 87.2 mP vs. 228.5 ± 69.2 mP, p = 0.016). Mean coronary high-shear WBV values obtained in ACS group were 15.6% higher than those in non-ACS group (42.9 ± 10.0 mP vs. 37.1 ± 4.6 mP, p = 0.036). CONCLUSIONS: Direct measurement of WBV from the coronary artery showed no differences with peripheral samples. Future larger studies are needed to clarify our results.
Keywords: Acute coronary syndrome, blood viscosity, wall shear stress, coronary vessels
DOI: 10.3233/CH-131692
Journal: Clinical Hemorheology and Microcirculation, vol. 55, no. 1, pp. 85-94, 2013
