The study of RBC deformability in NIDDM patients and its clinical implications

Article type: Research Article

Authors: Wen, Zong-yao | Ma, Wei-yuan | Jiang, Sheng-xian | Sun, Da-gong | Lu, Zhi-hong | Shi, Yen | Li, Yu-mei

Affiliations: Department of Medical Physics, Beijing Medical University, Beijing 100083 | Third Hospital of Beijing Medical University, Beijing 100083

Abstract: The maximum deformation indexes (DI)max and integration defromation index (IDI) of RBC in patients with noninsulin-dependent diabetes mellitus (NIDDM) were measured with Ektacytometry. Comparing with controls, (DI)max and 101 for NIDDM patients change with duration of NIDDM. No difference of (DI)max between less than 3 year-term NIDDM patients without complications and the controls was found but significant difference of IDI in this subgroup of patients was present. (DI)max, IDI in greater than 3 year-term NIDDM patients decreased with the duration of NlDDM when compared with the controls. Moreover, (DI)max and IDI were related with complications. These facts suggest that the duration or patient's condition in NIDDM patients might be judged by means of deformation indexes.

Keywords: erythrocyte deformability, noninsulin-dependent diabetes mellitus (NIDDM), duration ofNIODM

DOI: 10.3233/CH-1995-15607

Journal: Clinical Hemorheology and Microcirculation, vol. 15, no. 6, pp. 859-865, 1995