Microcirculation and blood rheology in patients with cerebrovascular disorders
Issue title: Selected Proceedings of the 16th Conference of the European Society for Clinical Hemorheology and Microcirculation (ESCHM), 18–21 June, 2011, Munich, Germany
Affiliations: Department of Anatomy and Physiology, State Pedagogical University, Yaroslavl, Russia
Note: [] Corresponding author: Irina A. Tikhomirova, Department of Anatomy and Physiology, Yaroslavl State Pedagogical University, Respublikanskaya 108, 150000 Yaroslavl, Russia. Tel.: +4852 312099; Fax: +4852 305596; E-mail: tikhom-irina@yandex.ru
Abstract: We estimated hemorheological parameters of vein blood samples and cutaneous microvascular blood flow in patients with acute ischemic stroke and in controls. The worsened blood rheological properties were registered in patients with stroke: the enhanced whole blood viscosity was due to the substantial increase of plasma viscosity and the impairment of microrheological blood properties: elevated erythrocyte aggregability and decreased deformability compared to the healthy group. The decrease of oxygen consumption fixed by rheological methods and by laser Doppler flowmetry led us to conclude that the tissue hypoxia took place in patients with stroke. The regulatory mechanisms aimed to maintain blood supply to tissue were activated under cerebral infarction and the impact of unfavorably changed rheological blood properties was markedly enhanced. Revealed close interrelations between rheological and microcirculation parameters testified the important role of hemorheological factors in maintenance of microvascular blood flow and oxygen delivery to tissue.
