Long-term infusional and oral therapy with pentoxiphylline in peripheral vasculopathy: A 3-year follow-up

Article type: Research Article

Authors: Allegra, C. | Carlizza, A. | Mari, A. | Sarcinella, R.

Affiliations: Department of Angiology, S. Giovanni Hospital, Rome, Italy

Abstract: We already demonstrated the efficacy of infusional therapy with pentoxiphylline in peripheral vasculopathy at 3rd and 4th Leriche-Fontaine degrees, without significant differences between results in POAD and diabetic patients. The present research aimed at verifying the effects of long-term oral therapy with pentoxiphylline after the first perfusion period. Haemorheological parameters (whole blood viscosity, haematocrit, platelet aggregation, fibrinogen, erythrocyte filterability) parallel with clinical parameters (walking distance, recovery time), kept and even improved, more or less significantly, the infusional therapy results throughout a 3-year follow-up of oral therapy alone.

Keywords: Peripheral obstructive arterial disease, Diabetic arteriopathy, Haemorheology, Pentoxiphylline

DOI: 10.3233/CH-1994-14311

Journal: Clinical Hemorheology and Microcirculation, vol. 14, no. 3, pp. 413-418, 1994