Cellular abnormalities in diabetes mellitus as factors in vascular complications

Article type: Review Article

Authors: Zoukourian, Clotilde | Wautier, Jean-Luc

Affiliations: Laboratoire de Biologie Vasculaire et Cellulaire, Paris VII, CHU Lariboisière; 2, rue A.Paré, 75010 Paris

Abstract: Blood cell and vascular cell dysfunctions have been observed in diabetes mellitus. Platelet hyperaggregability, monocyte dysfunctions, erythrocyte aggregability and adherence begin to be understood at the molecular level. The smooth muscle cell proliferation and the increase in vascular permeability could be related to cell-cell interactions or mediated via released factors such as cytokines or free radicals. A common but not exclusive explanation of these abnormalities could be non enzymatic glycosylation of lipids, proteins and cellular components.

Keywords: diabetes, endothelium, leukocyte, erythrocyte, glycation

DOI: 10.3233/CH-1994-14110

Journal: Clinical Hemorheology and Microcirculation, vol. 14, no. 1, pp. 63-73, 1994