Searching for just a few words should be enough to get started. If you need to make more complex queries, use the tips below to guide you.
Issue title: Alfred L. Copley Memorial Issue
Article type: Research Article
Authors: Maeda, T.; | Fisher, A.C. | Nash, G.B.
Affiliations: Department of Haematology, The Medical School, University of Birmingham, Birmingham | Bioengineering Unit, Strathclyde University, Glasgow, UK
Note: [] Current Address: 3rd Department of Medicine, Jikei University School of Medicine, 3-25-8 Nishi Shinbashi, Minato-Ku, Tokyo 105, Japan.
Abstract: Interaction between platelets and granulocytes may contribute to ischaemic and inflammatory disorders. We have used a recently developed granulocyte aggregation assay, in which isolated granulocytes and platelet-rich plasma (PRP) are mixed, to test the ability of a range of pharmacological agents to inhibit this interaction. A stable prostacyclin analogue (Iloprost) could completely inhibit platelet-induced granulocyte aggregation if the whole blood was treated immediately following withdrawal, but not if the agent was added to granulocytes or PRP after isolation. A surfactant (Poloxamer 188) added to the whole blood, either increased aggregation or had no effect, depending on the source of the compound under test. Naftidrofuryl oxalate and pentoxifylline tended to reduce aggregation, but these effects were not statistically significant. It appears that agents which can inhibit platelet activation may reduce adhesion to granulocytes, but are unable to reverse the interaction after the platelets have been stimulated.
Keywords: Leukocytes, Platelets, Aggregation, Drugs
DOI: 10.3233/CH-1992-12608
Journal: Clinical Hemorheology and Microcirculation, vol. 12, no. 6, pp. 857-865, 1992
IOS Press, Inc.
6751 Tepper Drive
Clifton, VA 20124
USA
Tel: +1 703 830 6300
Fax: +1 703 830 2300
sales@iospress.com
For editorial issues, like the status of your submitted paper or proposals, write to editorial@iospress.nl
IOS Press
Nieuwe Hemweg 6B
1013 BG Amsterdam
The Netherlands
Tel: +31 20 688 3355
Fax: +31 20 687 0091
info@iospress.nl
For editorial issues, permissions, book requests, submissions and proceedings, contact the Amsterdam office info@iospress.nl
Inspirees International (China Office)
Ciyunsi Beili 207(CapitaLand), Bld 1, 7-901
100025, Beijing
China
Free service line: 400 661 8717
Fax: +86 10 8446 7947
china@iospress.cn
For editorial issues, like the status of your submitted paper or proposals, write to editorial@iospress.nl
如果您在出版方面需要帮助或有任何建, 件至: editorial@iospress.nl