Rheological properties of red blood cell suspensions in fluorocarbon emulsion F-66E (blood substitute) and in each of its components

Article type: Research Article

Authors: Hamai, H. | Bucherer, C. | Ladjouzi, J. | Lacombe, C. | Lelievre, J.C. | Le Blanc, M.

Affiliations: Unité de Biorhéologie Université Paris 6 et CNRS URA 343, 91 bl de l'Hôpital, Pitié Salpêtrière, 75013 Paris, France | Laboratoire de Chimie Moléculaire, Université de Nice et CNRS URA 426, Parc Valrose, 06034 Nice, France

Abstract: Fluorocarbon emulsion were selected as intravascular carriers of respiratory gase because of their high capacity for dissolving them. For F-66E emulsion to be used medically, it is important to know the hemorheological consequences of a mixture of such an emulsion with blood. The present study is designed to investigate the rheological properties of red blood cell suspensions in F-66E emulsion and in each of its components, at fixed hematocrit (45 %) or variable hematocrit. Three different techniques are used: viscometry in static and dynamic flow conditions, aggregometry and flltrometry. The results indicate no perturbation of standard rheological properties of blood in the presence of F-66E emulsion.

Keywords: Blood substitute, F-66E Fluorocarbon emulsion, Oncotic agent, Haemorheology, Viscometry, Aggregometry, Filtrometry

DOI: 10.3233/CH-1992-12511

Journal: Clinical Hemorheology and Microcirculation, vol. 12, no. 5, pp. 733-745, 1992