Perfluorochemical blood substitutes: Circulatory and biomedical applications

Issue title: The Seventh European Conference on Clinical Hemorheology, Southampton, United Kingdom, 16–19 July 1991, Part I

Article type: Research Article

Authors: Lowe, Kenneth C.

Affiliations: Department of Life Science, university of Nottingham, University Park, Nottingham NG7 2RD, UK

Abstract: Perfluorochemicals (PFCs) are valuable in medicine, primarily as 02-carrying perfusates and tissue imaging agents. Their basic properties are described, including the need for emulsification before intravascular use. The formulation and assessment of PFC emulsions and their components in man and other species are discussed. Attention is focussed on the use of the commercial emulsion, Fluosol™ during clinical coronary angioplasty. Potential applications for PFCs in cancer therapy, ophthalmology, and the treatment of blood and respiratory disorders are also outlined.

Keywords: Perfluorochemicals, blood substitutes, biocompatibility, biomedical applications

DOI: 10.3233/CH-1992-12117

Journal: Clinical Hemorheology and Microcirculation, vol. 12, no. 1, pp. 141-156, 1992